A0A3B6KLC4 protein (Triticum aestivum) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

A0A3B6KLC4

AA_TRNA_LIGASE_II domain-containing protein. (466 aa)

Predicted Functional Partners:

A0A3B6IWJ8

0.976

A0A3B6JPG5

0.976

A0A3B6KTR7

0.976

A0A1D6RPZ0

0.965

A0A3B6C285

0.965

A0A3B6HSK0

0.965

A0A3B6IRR1

0.965

A0A3B6JKZ7

0.965

A0A3B6EB31

0.915

A0A3B6FGG6

0.915

Your Current Organism:

Triticum aestivum

NCBI taxonomy Id: 4565
Other names: Canadian hard winter wheat, T. aestivum, Triticum aestivum L., Triticum aestivum subsp. aestivum, Triticum vulgare, Triticum vulgare L., Triticum vulgare Vill., nom. illeg., bread wheat, common wheat, wheat

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1D6RPZ0	A0A3B6C285	S1 motif domain-containing protein.	S1 motif domain-containing protein.	0.543
A0A1D6RPZ0	A0A3B6HSK0	S1 motif domain-containing protein.	S1 motif domain-containing protein.	0.974
A0A1D6RPZ0	A0A3B6IRR1	S1 motif domain-containing protein.	S1 motif domain-containing protein.	0.974
A0A1D6RPZ0	A0A3B6JKZ7	S1 motif domain-containing protein.	S1 motif domain-containing protein.	0.974
A0A1D6RPZ0	A0A3B6KLC4	S1 motif domain-containing protein.	AA_TRNA_LIGASE_II domain-containing protein.	0.965
A0A3B6C285	A0A1D6RPZ0	S1 motif domain-containing protein.	S1 motif domain-containing protein.	0.543
A0A3B6C285	A0A3B6HSK0	S1 motif domain-containing protein.	S1 motif domain-containing protein.	0.974
A0A3B6C285	A0A3B6IRR1	S1 motif domain-containing protein.	S1 motif domain-containing protein.	0.974
A0A3B6C285	A0A3B6JKZ7	S1 motif domain-containing protein.	S1 motif domain-containing protein.	0.974
A0A3B6C285	A0A3B6KLC4	S1 motif domain-containing protein.	AA_TRNA_LIGASE_II domain-containing protein.	0.965
A0A3B6EB31	A0A3B6IWJ8	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein.	0.506
A0A3B6EB31	A0A3B6JPG5	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein.	0.506
A0A3B6EB31	A0A3B6KLC4	AA_TRNA_LIGASE_II domain-containing protein.	AA_TRNA_LIGASE_II domain-containing protein.	0.915
A0A3B6EB31	A0A3B6KTR7	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein.	0.506
A0A3B6FGG6	A0A3B6IWJ8	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein.	0.506
A0A3B6FGG6	A0A3B6JPG5	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein.	0.506
A0A3B6FGG6	A0A3B6KLC4	AA_TRNA_LIGASE_II domain-containing protein.	AA_TRNA_LIGASE_II domain-containing protein.	0.915
A0A3B6FGG6	A0A3B6KTR7	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein.	0.506
A0A3B6HSK0	A0A1D6RPZ0	S1 motif domain-containing protein.	S1 motif domain-containing protein.	0.974
A0A3B6HSK0	A0A3B6C285	S1 motif domain-containing protein.	S1 motif domain-containing protein.	0.974

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.873

expected number of edges:

18

PPI enrichment p-value:

0.0575

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019878

Lysine biosynthetic process via aminoadipic acid

5 of 15

3.5

7.3

5.56e-14

GO:0046394

Carboxylic acid biosynthetic process

10 of 1519

1.8

4.45

2.23e-14

GO:0019752

Carboxylic acid metabolic process

11 of 3200

1.52

3.21

3.14e-14

GO:0032787

Monocarboxylic acid metabolic process

6 of 1624

1.55

2.11

1.49e-06

GO:0008610

Lipid biosynthetic process

6 of 2299

1.4

1.69

9.65e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

5 of 11

3.64

7.34

5.17e-14

GO:0008897

Holo-[acyl-carrier-protein] synthase activity

5 of 11

3.64

7.34

5.17e-14

GO:0000036

Acyl carrier activity

5 of 33

3.16

6.36

1.98e-12

GO:0000287

Magnesium ion binding

5 of 516

1.97

2.96

3.02e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0110165

Cellular anatomical entity

11 of 19699

0.73

0.69

9.29e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:89305

Biotin metabolism, and ACP-like superfamily

6 of 91

2.8

6.02

3.75e-12

CL:89307

Biotin metabolism, and 4-phosphopantetheinyl transferase domain

4 of 71

2.73

3.59

2.02e-07

CL:97354

Mixed, incl. Chalcone/stilbene synthase, active site, and Pyrrolo-quinoline quinone beta-propeller repeat

3 of 12

3.38

3.36

8.54e-07

CL:89428

Mixed, incl. Phosphopantetheine binding, and 4-phosphopantetheinyl transferase domain

2 of 6

3.5

1.92

0.00036

CL:89452

Mixed, incl. ACP-like superfamily, and Serine/threonine-protein kinase BSK

2 of 16

3.08

1.66

0.0010

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00770

Pantothenate and CoA biosynthesis

5 of 148

2.51

4.77

4.41e-10

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-199220

Vitamin B5 (pantothenate) metabolism

6 of 99

2.76

6.5

3.48e-13

MAP-196849

Metabolism of water-soluble vitamins and cofactors

6 of 673

1.93

3.37

1.40e-08

MAP-196854

Metabolism of vitamins and cofactors

6 of 763

1.88

3.22

1.97e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034676

Integrin alpha6-beta4 complex

5 of 5

3.98

8.19

1.82e-15

GOCC:0110165

Cellular anatomical entity

6 of 8339

0.84

0.57

0.0104

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13570

PQQ-like domain

4 of 4

3.98

6.02

1.49e-11

PF01648

4-phosphopantetheinyl transferase superfamily

4 of 9

3.63

5.6

7.59e-11

PF13193

AMP-binding enzyme C-terminal domain

5 of 117

2.61

4.69

9.72e-10

PF00501

AMP-binding enzyme

5 of 170

2.45

4.24

4.53e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR018391

Pyrrolo-quinoline quinone beta-propeller repeat

5 of 7

3.83

7.48

3.23e-14

IPR002372

Pyrrolo-quinoline quinone repeat

5 of 11

3.64

7.21

8.92e-14

IPR036736

ACP-like superfamily

5 of 29

3.22

6.23

3.78e-12

IPR006162

Phosphopantetheine attachment site

5 of 29

3.22

6.23

3.78e-12

IPR037143

4-phosphopantetheinyl transferase domain superfamily

4 of 9

3.63

5.57

8.76e-11

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00564

Beta-propeller repeat

5 of 12

3.6

7.59

1.76e-14

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