A0A3B6LK88 protein (Triticum aestivum) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A3B6LK88

F-box domain-containing protein. (527 aa)

Predicted Functional Partners:

A0A3B6JGN3

0.898

A0A3B6EAB9

0.724

A0A3B6FDL0

0.724

A0A3B6NSW2

0.724

A0A3B6UA74

0.724

W5GNW2_WHEAT

0.724

A0A3B6NV53

0.697

A0A3B6PSJ8

0.697

A0A3B6QLR8

0.697

A0A1D6RH05

0.669

Your Current Organism:

Triticum aestivum

NCBI taxonomy Id: 4565
Other names: Canadian hard winter wheat, T. aestivum, Triticum aestivum L., Triticum aestivum subsp. aestivum, Triticum vulgare, Triticum vulgare L., Triticum vulgare Vill., nom. illeg., bread wheat, common wheat, wheat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1D6RH05	A0A3B6EAB9	A0A1D6RH05	A0A3B6EAB9	CULLIN_2 domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.959
A0A1D6RH05	A0A3B6FDL0	A0A1D6RH05	A0A3B6FDL0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.959
A0A1D6RH05	A0A3B6JGN3	A0A1D6RH05	A0A3B6JGN3	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.947
A0A1D6RH05	A0A3B6LK88	A0A1D6RH05	A0A3B6LK88	CULLIN_2 domain-containing protein; Belongs to the cullin family.	F-box domain-containing protein.	0.669
A0A1D6RH05	A0A3B6NSW2	A0A1D6RH05	A0A3B6NSW2	CULLIN_2 domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.959
A0A1D6RH05	A0A3B6UA74	A0A1D6RH05	A0A3B6UA74	CULLIN_2 domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.959
A0A1D6RH05	W5GNW2_WHEAT	A0A1D6RH05	W5GNW2	CULLIN_2 domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.959
A0A3B6EAB9	A0A1D6RH05	A0A3B6EAB9	A0A1D6RH05	RING-type domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.959
A0A3B6EAB9	A0A3B6JGN3	A0A3B6EAB9	A0A3B6JGN3	RING-type domain-containing protein.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.995
A0A3B6EAB9	A0A3B6LK88	A0A3B6EAB9	A0A3B6LK88	RING-type domain-containing protein.	F-box domain-containing protein.	0.724
A0A3B6EAB9	A0A3B6NSW2	A0A3B6EAB9	A0A3B6NSW2	RING-type domain-containing protein.	RING-type domain-containing protein.	0.946
A0A3B6EAB9	W5GNW2_WHEAT	A0A3B6EAB9	W5GNW2	RING-type domain-containing protein.	RING-type domain-containing protein.	0.946
A0A3B6FDL0	A0A1D6RH05	A0A3B6FDL0	A0A1D6RH05	RING-type domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.959
A0A3B6FDL0	A0A3B6JGN3	A0A3B6FDL0	A0A3B6JGN3	RING-type domain-containing protein.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.995
A0A3B6FDL0	A0A3B6LK88	A0A3B6FDL0	A0A3B6LK88	RING-type domain-containing protein.	F-box domain-containing protein.	0.724
A0A3B6FDL0	A0A3B6NSW2	A0A3B6FDL0	A0A3B6NSW2	RING-type domain-containing protein.	RING-type domain-containing protein.	0.946
A0A3B6FDL0	W5GNW2_WHEAT	A0A3B6FDL0	W5GNW2	RING-type domain-containing protein.	RING-type domain-containing protein.	0.946
A0A3B6JGN3	A0A1D6RH05	A0A3B6JGN3	A0A1D6RH05	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.947
A0A3B6JGN3	A0A3B6EAB9	A0A3B6JGN3	A0A3B6EAB9	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	RING-type domain-containing protein.	0.995
A0A3B6JGN3	A0A3B6FDL0	A0A3B6JGN3	A0A3B6FDL0	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	RING-type domain-containing protein.	0.995

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.654

expected number of edges:

16

PPI enrichment p-value:

0.0537

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006782

Protoporphyrinogen IX biosynthetic process

6 of 7

2.71

6.05

2.32e-12

GO:0006783

Heme biosynthetic process

7 of 14

2.48

5.91

1.07e-12

GO:1901362

Organic cyclic compound biosynthetic process

8 of 383

1.1

1.24

5.48e-06

GO:0044249

Cellular biosynthetic process

8 of 969

0.7

0.51

0.0043

GO:1901564

Organonitrogen compound metabolic process

10 of 1584

0.58

0.46

0.0012

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0102559

protein-(glutamine-N5) methyltransferase activity

2 of 2

2.78

0.94

0.0201

GO:0016634

Oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

2 of 3

2.6

0.93

0.0201

GO:0003824

Catalytic activity

11 of 2535

0.42

0.3

0.0201

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:21687966

(2011) Heme biosynthesis and its regulation: towards understanding and improvement of heme biosynthesis in filamentous fungi.

4 of 4

2.78

3.34

6.46e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8908

Heme biosynthetic process

6 of 11

2.52

5.17

6.22e-11

CL:8910

Siroheme metabolic process, and Protoporphyrinogen IX metabolic process

2 of 5

2.38

0.9

0.0223

CL:3456

Eukaryotic Translation Termination, and RF-1 domain

2 of 8

2.18

0.78

0.0357

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cne00860

Porphyrin and chlorophyll metabolism

7 of 19

2.34

5.95

2.23e-13

cne01110

Biosynthesis of secondary metabolites

8 of 332

1.16

1.46

3.69e-07

cne01100

Metabolic pathways

8 of 781

0.79

0.7

0.00018

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-189451

Heme biosynthesis

7 of 10

2.62

6.71

5.31e-14

MAP-189445

Metabolism of porphyrins

7 of 11

2.58

6.65

5.31e-14

MAP-1430728

Metabolism

9 of 1142

0.67

0.53

0.0017

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0627

Porphyrin biosynthesis

4 of 4

2.78

3.84

7.08e-08

KW-0350

Heme biosynthesis

2 of 3

2.6

1.37

0.0031

KW-0456

Lyase

3 of 50

1.56

1.02

0.0063

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05175

Methyltransferase small domain

2 of 4

2.48

0.84

0.0290

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007848

Methyltransferase small domain

2 of 2

2.78

0.81

0.0350

IPR002052

DNA methylase, N-6 adenine-specific, conserved site

2 of 4

2.48

0.75

0.0436

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