STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pseBUDP-N-acetylglucosamine 4,6-dehydratase (inverting); Epimerizes UDP-galactose to UDP-glucose; Belongs to the polysaccharide synthase family; KEGG: son:SO_3271 UDP-N-acetylglucosamine 4,6-dehydratase. (337 aa)    
Predicted Functional Partners:
ANS84160.1
UDP-4-amino-4, 6-dideoxy-N-acetyl-beta-L-altrosamine transaminase; Catalyzes the second step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Uses UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4- hexulose as substrate producing UDP-4-amino-4,6-dideoxy-beta-L- AltNAc; Belongs to the DegT/DnrJ/EryC1 family; KEGG: gfo:GFO_2027 null; Transaminases.
 
 
 0.989
neuA
N-acylneuraminate cytidylyltransferase; Belongs to the CMP-NeuNAc synthase family; KEGG: pwa:Pecwa_3030 N-acylneuraminate cytidylyltransferase.
 
  
 0.937
wecB
UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing); Catalyzes the conversion of UDP-N-acetylglucosamine into UDP-N-acetylmannosamine, a precursor of the teichoic acid linkage unit; Belongs to the UDP-N-acetylglucosamine 2-epimerase family; KEGG: vvu:VV1_0780 UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing).
  
 
 0.936
neuB
N-acetylneuraminate synthase; Catalyzes the fifth step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Catalyzes the condensation of phosphoenolpyruvate with 2,4-diacetamido-2,4,6-trideoxy-beta-l-altropyranose, forming pseudaminic acid (By similarity); Belongs to the pseudaminic acid synthase family; Contains 1 AFP-like domain; KEGG: psh:Psest_1815 N-acetylneuraminate synthase.
 
  
 0.922
pseG
KEGG: dru:Desru_1220 UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase.
 
   
 0.921
wbpP
Catalyzes the epimerization of UDP-N-acetylglucosamine (UDP-GlcNAc) to UDP-N-acetylgalactosamine (UDP-GalNAc). Has very low epimerase activity with UDP-Glc and UDP-Gal. Plays a role in the biosynthesis of 2-acetamino-2-deoxy-L-altruronic acid, a building block of the O-antigen in bacterial lipopolysaccharide (LPS); Belongs to the NAD(P)-dependent epimerase/dehydratase family; KEGG: vcy:IX92_15295 UDP-N-acetylglucosamine 4-epimerase.
 
 
0.920
wbpO
Vi polysaccharide biosynthesis protein VipA/TviB; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family; KEGG: ppno:DA70_17265 UDP-N-acetyl-D-galactosamine dehydrogenase; With NAD(+) or NADP(+) as acceptor.
  
 
 0.916
glmU
UDP-N-acetylglucosamine diphosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.
    
 0.915
ANS84165.1
Hypothetical protein.
 
   
 0.909
murA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
    
 0.907
Your Current Organism:
Vibrio scophthalmi
NCBI taxonomy Id: 45658
Other names: CAIM 75, CECT 4638, CIP 105211, LMG 19158, LMG:19158, V. scophthalmi, strain A089
Server load: medium (72%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.