STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aceEPyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)    
Predicted Functional Partners:
dlaT
Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.998
pdhD-2
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity); Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family; KEGG: vch:VC2412 dihydrolipoamide dehydrogenase.
 
 
 0.985
pdhD
Dihydrolipoyl dehydrogenase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family; KEGG: van:VAA_02624 dihydrolipoamide dehydrogenase.
  
 
 0.944
oadA
Oxaloacetate decarboxylase; The 5S subunit specifically catalyzes the transfer of the carboxyl group from biotin of the 1. 3S subunit to pyruvate to form oxaloacetate and 1. 3S biotin. Contains 1 carboxyltransferase domain; KEGG: vch:VC0550 oxaloacetate decarboxylase, alpha subunit.
  
 
 0.938
ANS86574.1
Belongs to the pyruvate kinase family; KEGG: eco:b1676 pyruvate kinase.
  
 
 0.918
ANS87386.1
Belongs to the pyruvate kinase family; KEGG: pwa:Pecwa_3622 pyruvate kinase.
  
 
 0.918
maeB
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); Required for symbiotic nitrogen fixation. Plays a key role in the conversion of malate to acetyl-CoA for efficient tricarboxylic acid cycle function in nitrogen-fixating bacteria. In the N-terminal sectio; belongs to the malic enzymes family; In the C-terminal sectio; belongs to the phosphate acetyltransferase and butyryltransferase family; KEGG: vvu:VV1_1361 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+).
    
 0.915
sfcA
Belongs to the malic enzymes family; KEGG: vch:VC1188 malate dehydrogenase (oxaloacetate-decarboxylating).
    
 0.915
ldhA
D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family; KEGG: vpa:VPA0144 D-lactate dehydrogenase.
     
 0.906
dlsT
Dihydrolipoyllysine-residue succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 
 0.905
Your Current Organism:
Vibrio scophthalmi
NCBI taxonomy Id: 45658
Other names: CAIM 75, CECT 4638, CIP 105211, LMG 19158, LMG:19158, V. scophthalmi, strain A089
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.