node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
folB | folC | VSVS12_02786 | VSVS12_02273 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydrofolate synthase; Conversion of folates to polyglutamate derivatives; Belongs to the folylpolyglutamate synthase family; KEGG: vcy:IX92_03655 dihydrofolate synthase / folylpolyglutamate synthase. | 0.661 |
folB | folK | VSVS12_02786 | VSVS12_00680 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Belongs to the HPPK family; KEGG: hin:HI0064 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | 0.991 |
folB | folK-2 | VSVS12_02786 | VSVS12_02785 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | KEGG: vpa:VP0412 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | 0.997 |
folB | folP | VSVS12_02786 | VSVS12_00727 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
folB | gch1 | VSVS12_02786 | VSVS12_03796 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Belongs to the GTP cyclohydrolase I family; KEGG: vch:VCA0616 GTP cyclohydrolase I. | 0.971 |
folB | ribD | VSVS12_02786 | VSVS12_00853 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.510 |
folC | folB | VSVS12_02273 | VSVS12_02786 | Dihydrofolate synthase; Conversion of folates to polyglutamate derivatives; Belongs to the folylpolyglutamate synthase family; KEGG: vcy:IX92_03655 dihydrofolate synthase / folylpolyglutamate synthase. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.661 |
folC | folK | VSVS12_02273 | VSVS12_00680 | Dihydrofolate synthase; Conversion of folates to polyglutamate derivatives; Belongs to the folylpolyglutamate synthase family; KEGG: vcy:IX92_03655 dihydrofolate synthase / folylpolyglutamate synthase. | Belongs to the HPPK family; KEGG: hin:HI0064 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | 0.688 |
folC | folK-2 | VSVS12_02273 | VSVS12_02785 | Dihydrofolate synthase; Conversion of folates to polyglutamate derivatives; Belongs to the folylpolyglutamate synthase family; KEGG: vcy:IX92_03655 dihydrofolate synthase / folylpolyglutamate synthase. | KEGG: vpa:VP0412 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | 0.580 |
folC | folP | VSVS12_02273 | VSVS12_00727 | Dihydrofolate synthase; Conversion of folates to polyglutamate derivatives; Belongs to the folylpolyglutamate synthase family; KEGG: vcy:IX92_03655 dihydrofolate synthase / folylpolyglutamate synthase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
folC | gch1 | VSVS12_02273 | VSVS12_03796 | Dihydrofolate synthase; Conversion of folates to polyglutamate derivatives; Belongs to the folylpolyglutamate synthase family; KEGG: vcy:IX92_03655 dihydrofolate synthase / folylpolyglutamate synthase. | Belongs to the GTP cyclohydrolase I family; KEGG: vch:VCA0616 GTP cyclohydrolase I. | 0.670 |
folC | ribD | VSVS12_02273 | VSVS12_00853 | Dihydrofolate synthase; Conversion of folates to polyglutamate derivatives; Belongs to the folylpolyglutamate synthase family; KEGG: vcy:IX92_03655 dihydrofolate synthase / folylpolyglutamate synthase. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.484 |
folK | folB | VSVS12_00680 | VSVS12_02786 | Belongs to the HPPK family; KEGG: hin:HI0064 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.991 |
folK | folC | VSVS12_00680 | VSVS12_02273 | Belongs to the HPPK family; KEGG: hin:HI0064 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | Dihydrofolate synthase; Conversion of folates to polyglutamate derivatives; Belongs to the folylpolyglutamate synthase family; KEGG: vcy:IX92_03655 dihydrofolate synthase / folylpolyglutamate synthase. | 0.688 |
folK | folK-2 | VSVS12_00680 | VSVS12_02785 | Belongs to the HPPK family; KEGG: hin:HI0064 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | KEGG: vpa:VP0412 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | 0.922 |
folK | folP | VSVS12_00680 | VSVS12_00727 | Belongs to the HPPK family; KEGG: hin:HI0064 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
folK | gch1 | VSVS12_00680 | VSVS12_03796 | Belongs to the HPPK family; KEGG: hin:HI0064 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | Belongs to the GTP cyclohydrolase I family; KEGG: vch:VCA0616 GTP cyclohydrolase I. | 0.987 |
folK | gluQ | VSVS12_00680 | VSVS12_00682 | Belongs to the HPPK family; KEGG: hin:HI0064 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | Glutamyl-Q tRNA(Asp) synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. | 0.580 |
folK | panB | VSVS12_00680 | VSVS12_00679 | Belongs to the HPPK family; KEGG: hin:HI0064 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.828 |
folK | panC | VSVS12_00680 | VSVS12_00678 | Belongs to the HPPK family; KEGG: hin:HI0064 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | Pantoate--beta-alanine ligase (AMP-forming); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.832 |