STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
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[Homology]
Score
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (372 aa)    
Predicted Functional Partners:
metL
Aspartate kinase; In the N-terminal sectio; belongs to the aspartokinase family; In the C-terminal sectio; belongs to the homoserine dehydrogenase family; KEGG: vpa:VP2764 bifunctional aspartokinase / homoserine dehydrogenase 2.
  
 0.989
thrA
Aspartate kinase; In the N-terminal sectio; belongs to the aspartokinase family; In the C-terminal sectio; belongs to the homoserine dehydrogenase family; Contains 2 ACT domains; KEGG: eco:b0002 bifunctional aspartokinase / homoserine dehydrogenase 1.
  
 0.989
lysC
Belongs to the aspartokinase family; Contains 1 ACT domain; KEGG: vch:VC0391 aspartate kinase.
  
 
 0.954
lysC-2
Aspartate kinase; Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine; Belongs to the aspartokinase family; Contains 2 ACT domains; KEGG: vch:VC0547 aspartate kinase.
  
 
 0.954
dapA
4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
  
 
 0.942
ectB
Diaminobutyrate--2-oxoglutarate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family; KEGG: vvu:VV1_3050 diaminobutyrate-2-oxoglutarate transaminase.
    
 0.915
doeD
Diaminobutyrate--2-oxoglutarate transaminase; Involved in the biosynthesis of ectoine ((S)-2-methyl- 1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the conversion of L-2,4-diaminobutyrate (DABA) to L- aspartate beta-semialdehyde (ASA) by transamination with 2- oxoglutarate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family; KEGG: vag:N646 [...]
    
 0.912
doeC
Belongs to the aldehyde dehydrogenase family; KEGG: vag:N646_3798 aspartate-semialdehyde dehydrogenase; With NAD(+) or NADP(+) as acceptor.
   
 
 0.905
asd-2
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
     
 
0.900
dapF
Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.
  
  
 0.646
Your Current Organism:
Vibrio scophthalmi
NCBI taxonomy Id: 45658
Other names: CAIM 75, CECT 4638, CIP 105211, LMG 19158, LMG:19158, V. scophthalmi, strain A089
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