STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ANS85573.1Response regulator ArlR; Member of the two-component regulatory system ArlS/ArlR; Contains 1 OmpR/PhoB-type DNA-binding domain; Contains 1 response regulatory domain. (221 aa)    
Predicted Functional Partners:
cpxA-2
Histidine kinase; This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synthesis, translocation, or stability of cell envelope proteins. Activates CpxR by phosphorylation (By similarity); Contains 1 HAMP domain; Contains 1 histidine kinase domain; KEGG: vvu:VV1_1253 two-component system, OmpR family, sensor histidine kinase CpxA.
 
 0.986
cpxA
Histidine kinase; Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity); Contains 1 HAMP domain; Contains 1 histidine kinase domain; KEGG: llo:LLO_1782 two-component system, OmpR family, sensor histidine kinase CpxA.
 
 
 0.964
evgS
Histidine kinase; Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling. Belongs to the ethylene receptor family; Contains 1 GAF domain; Contains 1 histidine kinase domain; KEGG: van:VAA_03253 two-component system, NarL family, sensor histidine kinase EvgS.
 
 
 0.942
arcB-2
Histidine kinase; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His- 717 and Asp-576 (By similarity); Contains 1 histidine kinase domain; Contains 1 HPt domain; Contains 1 PAC (PAS-associated C-terminal) domain; Contains 1 PAS (PER-ARNT-SIM) domain; Contains 1 response regulatory domain; KEGG: vch:VC2369 two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB.
 
 0.931
torS
Histidine kinase; Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Detects the presence of TMAO in the medium and, in response, activates TorR via a four-step phosphorelay. When TMAO is removed, TorS can dephosphorylate TorR, probably by a reverse phosphorelay involving His-860 and Asp-733 (By similarity); Contains 1 HAMP domain; Contains 1 histidine kinase domain; Contains 1 HPt domain; Contains 1 response regulatory domain; KEGG: vch:VCA0709 two-component system, OmpR family, sensor histidine kinase TorS.
 
 
 0.913
ANS86686.1
Response regulator SaeR; Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs near the promoter sequences of target genes (By similarity); Contains 1 OmpR/PhoB-type DNA-binding domain; Contains 1 response regulatory domain.
  
  
 
0.909
ANS87397.1
Heme sensor protein HssS; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity); Contains 1 HAMP domain; Contains 1 histidine kinase domain; KEGG: pen:PSEEN1361 null; Phosphotransferases with a nitr [...]
 
 
 0.871
barA
Histidine kinase; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity); Contains 1 HAMP domain; Contains 1 histidine kinase domain; Contains 1 HPt domain; Contains 1 response regulatory domain; KEGG: vvu:VV1_1573 two-component system, NarL family, sensor histidine kinase BarA.
 
 0.870
cqsS
CAI-1 autoinducer sensor kinase/phosphatase CqsS; Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to LuxU and LuxO; Contains 1 histidine kinase domain; Contains 1 response regulatory domain; KEGG: vpa:VPA0710 two-component system, CAI-1 autoinducer sensor kinase/phosphatase CqsS; Histidine kinase.
 
 
 0.858
ANS85896.1
Histidine kinase; Cytokinins (CK) receptor related to bacterial two- component regulators. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. In the presence of cytokinin, feed phosphate to phosphorelay-integrating histidine phosphotransfer protein (HPt) and activates subsequent cascade. Involved in meristems establishment in seedling [...]
 
 
 0.846
Your Current Organism:
Vibrio scophthalmi
NCBI taxonomy Id: 45658
Other names: CAIM 75, CECT 4638, CIP 105211, LMG 19158, LMG:19158, V. scophthalmi, strain A089
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