STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdaAL-serine ammonia-lyase; Deaminates also threonine, particularly when it is present in high concentration. Belongs to the iron-sulfur dependent L-serine dehydratase family; KEGG: eco:b1814 L-serine dehydratase. (453 aa)    
Predicted Functional Partners:
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.947
ilvA
Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.923
cysE
Serine O-acetyltransferase; Belongs to the transferase hexapeptide repeat family; KEGG: mvr:X781_3590 serine O-acetyltransferase.
     
 0.910
agxT
Alanine--glyoxylate transaminase; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family; KEGG: vni:VIBNI_A3034 alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase.
    
 0.907
serB
Catalyzes the dephosphorylation of phosphoserine (P- Ser); Belongs to the SerB family; KEGG: vch:VC2345 phosphoserine phosphatase.
   
 
 0.907
ANS87304.1
L-serine ammonia-lyase; Deaminates also threonine, particularly when it is present in high concentration. Belongs to the iron-sulfur dependent L-serine dehydratase family; KEGG: eco:b1814 L-serine dehydratase.
  
  
 
0.903
trpA
Tryptophan synthase; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
   
 
 0.901
pssA
CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-II family; Contains 2 PLD phosphodiesterase domains; KEGG: vfu:vfu_A00050 CDP-diacylglycerol---serine O-phosphatidyltransferase.
     
  0.900
trpB
Tryptophan synthase; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.900
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.836
Your Current Organism:
Vibrio scophthalmi
NCBI taxonomy Id: 45658
Other names: CAIM 75, CECT 4638, CIP 105211, LMG 19158, LMG:19158, V. scophthalmi, strain A089
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