STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
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[Homology]
Score
ANS85773.1Member of the two-component regulatory system DesR/DesK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase; Contains 1 HTH luxR-type DNA-binding domain; Contains 1 response regulatory domain. (214 aa)    
Predicted Functional Partners:
barA
Histidine kinase; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity); Contains 1 HAMP domain; Contains 1 histidine kinase domain; Contains 1 HPt domain; Contains 1 response regulatory domain; KEGG: vvu:VV1_1573 two-component system, NarL family, sensor histidine kinase BarA.
 
 
 0.993
evgS
Histidine kinase; Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling. Belongs to the ethylene receptor family; Contains 1 GAF domain; Contains 1 histidine kinase domain; KEGG: van:VAA_03253 two-component system, NarL family, sensor histidine kinase EvgS.
 
 
 
 0.887
arcB-2
Histidine kinase; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His- 717 and Asp-576 (By similarity); Contains 1 histidine kinase domain; Contains 1 HPt domain; Contains 1 PAC (PAS-associated C-terminal) domain; Contains 1 PAS (PER-ARNT-SIM) domain; Contains 1 response regulatory domain; KEGG: vch:VC2369 two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB.
 
 
 
 0.876
torS
Histidine kinase; Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Detects the presence of TMAO in the medium and, in response, activates TorR via a four-step phosphorelay. When TMAO is removed, TorS can dephosphorylate TorR, probably by a reverse phosphorelay involving His-860 and Asp-733 (By similarity); Contains 1 HAMP domain; Contains 1 histidine kinase domain; Contains 1 HPt domain; Contains 1 response regulatory domain; KEGG: vch:VCA0709 two-component system, OmpR family, sensor histidine kinase TorS.
 
 
 
 0.831
uvrC
UvrABC system protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
     
 0.798
narQ
Histidine kinase; Acts as a sensor for nitrate/nitrite and transduces signal of nitrate/nitrite availability to the NarL/NarP proteins. NarQ probably activates NarL and NarP by phosphorylation. NarQ probably negatively regulates the NarL protein by dephosphorylation. Contains 1 HAMP domain; Contains 1 histidine kinase domain; KEGG: vvu:VV2_0719 two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ.
 
 0.706
ANS85187.1
Ethylene receptor related to bacterial two-component regulators. Acts as negative regulator of ethylene signaling. May delay the transition from the vegetative stage to the floral stage by upregulating GI (GIGANTEA) and RCN1 and cause starch accumulation in stems by down-regulating the alpha-amylase AMY3D; Belongs to the ethylene receptor family; Contains 1 GAF domain; Contains 1 histidine kinase domain; Contains 1 response regulatory domain.
 
 
 0.703
baeS
Histidine kinase; Ethylene receptor related to bacterial two-component regulators. Acts as negative regulator of ethylene signaling. May delay the transition from the vegetative stage to the floral stage by upregulating GI (GIGANTEA) and RCN1 and cause starch accumulation in stems by down-regulating the alpha-amylase AMY3D; Belongs to the ethylene receptor family; Contains 1 GAF domain; Contains 1 histidine kinase domain; Contains 1 response regulatory domain; KEGG: mah:MEALZ_3850 two-component system, OmpR family, sensor histidine kinase BaeS.
 
 
 0.655
ANS85640.1
Histidine kinase; Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for malate; Contains 1 HAMP domain; Contains 1 methyl-accepting transducer domain; KEGG: vvu:VV1_2240 two-component system, NarL family, sensor kinase.
 
     0.636
ANS87978.1
Putative transcriptional regulatory protein YhcZ; Member of the two-component regulatory system YhcY/YhcZ; Contains 1 HTH luxR-type DNA-binding domain; Contains 1 response regulatory domain.
  
     0.635
Your Current Organism:
Vibrio scophthalmi
NCBI taxonomy Id: 45658
Other names: CAIM 75, CECT 4638, CIP 105211, LMG 19158, LMG:19158, V. scophthalmi, strain A089
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