STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANS86226.1Macrolide export protein; Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP-bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, MacA binds tightly rough-core lipopolysaccharide (R- LPS), suggesting that the system could also transport R-LPS or a similar [...] (358 aa)    
Predicted Functional Partners:
ANS83947.1
Putative transporter; Could be a drug efflux pump; Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family.
 
 0.986
ANS86225.1
Putative transporter; Could be a drug efflux pump; Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family.
 
 
 0.971
ANS86835.1
The inner membrane transporter component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin, chloramphenicol, erythromycin, novobiocin, streptomycin and tetracycline. Is not involved in organic solvent efflux. Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family.
 
 0.969
ANS86350.1
Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells; Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family.
 
 0.954
ANS87503.1
The inner membrane transporter component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin, chloramphenicol, erythromycin, novobiocin, streptomycin and tetracycline. Is not involved in organic solvent efflux. Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family.
 
 
 0.818
ANS83946.1
Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family.
  
  
 
0.656
ANS84513.1
Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family.
  
  
 
0.631
ANS85094.1
Swarming motility protein SwrC; Required for self-resistance to surfactin, an antimicrobial lipopeptide surfactant produced by B. subtilis. Also required for swarming motility; Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family.
 
 
 0.605
ANS85805.1
Nodulation protein NolG; Involved in the production of Medicago-specific nodulation signal molecule. Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family.
 
 
 0.601
ANS85250.1
Multidrug resistance protein MdtB; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate; Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MdtB subfamily.
 
 
 0.600
Your Current Organism:
Vibrio scophthalmi
NCBI taxonomy Id: 45658
Other names: CAIM 75, CECT 4638, CIP 105211, LMG 19158, LMG:19158, V. scophthalmi, strain A089
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