STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ANS86352.1Nitrogen assimilation regulatory protein NtrC; Member of the two-component regulatory system NtrB/NtrC involved in the activation of nitrogen assimilatory genes such as GlnA. NtrC is phosphorylated by NtrB and interacts with sigma-54. Contains 1 response regulatory domain; Contains 1 sigma-54 factor interaction domain. (444 aa)    
Predicted Functional Partners:
ANS84345.1
RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.784
glnL
Histidine kinase; NtrB acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of NtrC. In nitrogen limitation NtrB activates NtrC by phosphorylating it, while in nitrogen excess NtrC is dephosphorylated and consequently inactivated by NtrB (By similarity); Contains 1 histidine kinase domain; Contains 1 PAS (PER-ARNT-SIM) domain; KEGG: vcy:IX92_15680 two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL.
 
 0.553
ANS87868.1
Non-specific serine/threonine protein kinase; Regulates the activity of endogenous beta-lactamase or related enzymes, by blocking their secretion by phosphorylation, in response to an external signal yet to be identified. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family; Contains 1 guanylate cyclase domain; Contains 1 protein kinase domain; KEGG: chy:CHY_1478 serine/threonine protein kinase, bacterial.
 
 
 0.498
barA
Histidine kinase; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity); Contains 1 HAMP domain; Contains 1 histidine kinase domain; Contains 1 HPt domain; Contains 1 response regulatory domain; KEGG: vvu:VV1_1573 two-component system, NarL family, sensor histidine kinase BarA.
  
 
 0.494
ANS86351.1
Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family.
       0.479
ANS87249.1
Sensor protein; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals (By similarity); Contains 1 histidine kinase domain; Contains 1 HPt domain; Contains 1 response regulatory domain.
  
 
 0.479
cheA
Histidine kinase; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylate; it can transfer its phosphate group to either CheB or CheY (By similarity); Contains 1 cheW-like domain; Contains 1 histidine kinase domain; Contains 1 HPt domain; KEGG: vch:VC2063 two-component system, chemotaxis family, sensor kinase CheA.
  
 
 0.469
ANS86016.1
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; In the N-terminal sectio; belongs to the MIP18 family; In the C-terminal sectio; belongs to the Mrp/NBP35 ATP-binding proteins family.
  
 
 0.466
ANS84507.1
Transducer protein Htr6; Potentially involved in chemo- or phototactic signal transduction; Contains 2 HAMP domains; Contains 1 methyl-accepting transducer domain; KEGG: vfi:VF_2138 null; Phosphotransferases with a nitrogenous group as acceptor.
  
 
 0.464
arcB-2
Histidine kinase; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His- 717 and Asp-576 (By similarity); Contains 1 histidine kinase domain; Contains 1 HPt domain; Contains 1 PAC (PAS-associated C-terminal) domain; Contains 1 PAS (PER-ARNT-SIM) domain; Contains 1 response regulatory domain; KEGG: vch:VC2369 two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB.
  
 
 0.464
Your Current Organism:
Vibrio scophthalmi
NCBI taxonomy Id: 45658
Other names: CAIM 75, CECT 4638, CIP 105211, LMG 19158, LMG:19158, V. scophthalmi, strain A089
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