node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANS87297.1 | cobA | VSVS12_03588 | VSVS12_00505 | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_08050 uroporphy [...] | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_14505 uroporphy [...] | 0.903 |
ANS87297.1 | hemB | VSVS12_03588 | VSVS12_00122 | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_08050 uroporphy [...] | Porphobilinogen synthase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family; KEGG: vch:VC0105 porphobilinogen synthase. | 0.862 |
ANS87297.1 | hemC | VSVS12_03588 | VSVS12_00042 | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_08050 uroporphy [...] | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.985 |
ANS87297.1 | hemD | VSVS12_03588 | VSVS12_00043 | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_08050 uroporphy [...] | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.922 |
ANS87297.1 | hemE | VSVS12_03588 | VSVS12_02932 | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_08050 uroporphy [...] | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.920 |
ANS87297.1 | hemL | VSVS12_03588 | VSVS12_00714 | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_08050 uroporphy [...] | Glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily; KEGG: yro:CH64_3351 glutamate-1-semialdehyde 2,1-aminomutase. | 0.715 |
ANS87297.1 | hemX | VSVS12_03588 | VSVS12_00044 | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_08050 uroporphy [...] | KEGG: vpa:VP2990 uroporphyrin-III C-methyltransferase. | 0.902 |
cobA | ANS87297.1 | VSVS12_00505 | VSVS12_03588 | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_14505 uroporphy [...] | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_08050 uroporphy [...] | 0.903 |
cobA | hemB | VSVS12_00505 | VSVS12_00122 | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_14505 uroporphy [...] | Porphobilinogen synthase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family; KEGG: vch:VC0105 porphobilinogen synthase. | 0.857 |
cobA | hemC | VSVS12_00505 | VSVS12_00042 | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_14505 uroporphy [...] | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.975 |
cobA | hemD | VSVS12_00505 | VSVS12_00043 | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_14505 uroporphy [...] | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.922 |
cobA | hemE | VSVS12_00505 | VSVS12_02932 | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_14505 uroporphy [...] | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.920 |
cobA | hemL | VSVS12_00505 | VSVS12_00714 | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_14505 uroporphy [...] | Glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily; KEGG: yro:CH64_3351 glutamate-1-semialdehyde 2,1-aminomutase. | 0.702 |
cobA | hemX | VSVS12_00505 | VSVS12_00044 | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme; In the N-terminal sectio; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family; In the C-terminal sectio; belongs to the precorrin methyltransferase family; KEGG: vcy:IX92_14505 uroporphy [...] | KEGG: vpa:VP2990 uroporphyrin-III C-methyltransferase. | 0.902 |
cpoX | hemB | VSVS12_00262 | VSVS12_00122 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Porphobilinogen synthase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family; KEGG: vch:VC0105 porphobilinogen synthase. | 0.537 |
cpoX | hemC | VSVS12_00262 | VSVS12_00042 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.563 |
cpoX | hemD | VSVS12_00262 | VSVS12_00043 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.479 |
cpoX | hemE | VSVS12_00262 | VSVS12_02932 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.962 |
cpoX | hemH | VSVS12_00262 | VSVS12_00955 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Protoporphyrin ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.643 |
cpoX | hemN | VSVS12_00262 | VSVS12_00115 | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Coproporphyrinogen dehydrogenase; Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. It can use NAD or NADP, but NAD is preferred; Belongs to the anaerobic coproporphyrinogen-III oxidase family; KEGG: vcy:IX92_00390 oxygen-independent coproporphyrinogen III oxidase. | 0.920 |