STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANS87202.1Hypothetical protein. (367 aa)    
Predicted Functional Partners:
ANS86363.1
Diguanylate cyclase (DGC) that catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V. cholerae, and is proposed to play an important role in the transition from persistence in the environment to survival in the host. Overexpression of vdcA results in increased biofilm formation, and reduced motility and virulence; Contains 1 GGDEF domain.
 
 0.874
ANS85272.1
Protein AdrA; Contains 1 GGDEF domain.
 
 
 0.873
ANS87424.1
HTH-type transcriptional regulator MalR; Transcriptional repressor of the maltosaccharide utilization operon malEFG. Contains 1 HTH lacI-type DNA-binding domain.
 
 0.831
ANS87974.1
Protein-glutamate O-methyltransferase; Plays an essential role in the maintenance and the formation of the three-dimensional structure of the biofilms at the later stages of their development. Absence of mbaA promotes the accumulation of larger amount of biomass on the surfaces at later stage of development, results in the overproduction of an extracellular polymeric substance that accumulates in the matrix of biofilms. This yields biofilms lacking the typical structure consisting of pillars of cells separated by fluid filled channels; Contains 1 EAL domain; Contains 1 GGDEF domain; Co [...]
   0.819
pleD-2
Diguanylate cyclase; Contains 1 EAL domain; Contains 1 GGDEF domain; Contains 1 MHYT domain; Contains 1 PAS (PER-ARNT-SIM) domain; KEGG: csq:CSCA_1240 two-component system, cell cycle response regulator.
 
     0.809
ANS84091.1
Diguanylate cyclase DosC; Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus, catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria (By similarity); Contains 1 GGDEF domain.
    0.806
arcB
Histidine kinase; Contains 1 GGDEF domain; KEGG: eca:ECA0314 two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB.
 
 0.806
ANS85605.1
Cyclic di-GMP phosphodiesterase PdeB; Affects motility and biofilm formation, and is linked to the regulation of sulfate uptake and assimilation; Contains 1 EAL domain; Contains 1 GGDEF domain; Contains 1 PAS (PER-ARNT-SIM) domain.
 
 0.805
pleD
Diguanylate cyclase; Involves in the regulation of cellulose production; Contains 1 GGDEF domain; KEGG: tig:THII_0061 two-component system, cell cycle response regulator.
 
 0.803
evgS-2
Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity); Contains 12 HAMP domains; Contains 1 histidine kinase domain; Contains 2 response regulatory domains; KEGG: pec:W5S_1553 two-component system, NarL family, sensor histidine kinase EvgS.
 
  
 0.797
Your Current Organism:
Vibrio scophthalmi
NCBI taxonomy Id: 45658
Other names: CAIM 75, CECT 4638, CIP 105211, LMG 19158, LMG:19158, V. scophthalmi, strain A089
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.