node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANS87311.1 | ANS87313.1 | VSVS12_03602 | VSVS12_03604 | Cytochrome c-554(548). | ADP-ribose diphosphatase; Involved in the activation of the NAD-dependent methanol dehydrogenase (MDH). MDH activation by Act involves hydrolytic removal of the nicotinamide mononucleotide (NMN) moiety of the NAD cofactor, changing its ping-pong type of reaction mechanism into a ternary complex reaction mechanism. It requires the presence of magnesium ions and is also able to use ADP-ribose; Belongs to the Nudix hydrolase family; KEGG: vni:VIBNI_B0914 ADP-ribose pyrophosphatase. | 0.453 |
ANS87311.1 | ltaE | VSVS12_03602 | VSVS12_03603 | Cytochrome c-554(548). | Belongs to the threonine aldolase family; KEGG: vch:VCA0765 threonine aldolase. | 0.512 |
ANS87313.1 | ANS87311.1 | VSVS12_03604 | VSVS12_03602 | ADP-ribose diphosphatase; Involved in the activation of the NAD-dependent methanol dehydrogenase (MDH). MDH activation by Act involves hydrolytic removal of the nicotinamide mononucleotide (NMN) moiety of the NAD cofactor, changing its ping-pong type of reaction mechanism into a ternary complex reaction mechanism. It requires the presence of magnesium ions and is also able to use ADP-ribose; Belongs to the Nudix hydrolase family; KEGG: vni:VIBNI_B0914 ADP-ribose pyrophosphatase. | Cytochrome c-554(548). | 0.453 |
ANS87313.1 | ltaE | VSVS12_03604 | VSVS12_03603 | ADP-ribose diphosphatase; Involved in the activation of the NAD-dependent methanol dehydrogenase (MDH). MDH activation by Act involves hydrolytic removal of the nicotinamide mononucleotide (NMN) moiety of the NAD cofactor, changing its ping-pong type of reaction mechanism into a ternary complex reaction mechanism. It requires the presence of magnesium ions and is also able to use ADP-ribose; Belongs to the Nudix hydrolase family; KEGG: vni:VIBNI_B0914 ADP-ribose pyrophosphatase. | Belongs to the threonine aldolase family; KEGG: vch:VCA0765 threonine aldolase. | 0.687 |
agxT | gcaT | VSVS12_00580 | VSVS12_03653 | Alanine--glyoxylate transaminase; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family; KEGG: vni:VIBNI_A3034 alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase. | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.911 |
agxT | gldC | VSVS12_00580 | VSVS12_04284 | Alanine--glyoxylate transaminase; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family; KEGG: vni:VIBNI_A3034 alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase. | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.938 |
agxT | glyA | VSVS12_00580 | VSVS12_00907 | Alanine--glyoxylate transaminase; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family; KEGG: vni:VIBNI_A3034 alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.941 |
agxT | ilvA | VSVS12_00580 | VSVS12_00220 | Alanine--glyoxylate transaminase; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family; KEGG: vni:VIBNI_A3034 alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase. | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.926 |
agxT | ltaE | VSVS12_00580 | VSVS12_03603 | Alanine--glyoxylate transaminase; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family; KEGG: vni:VIBNI_A3034 alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase. | Belongs to the threonine aldolase family; KEGG: vch:VCA0765 threonine aldolase. | 0.931 |
gcaT | agxT | VSVS12_03653 | VSVS12_00580 | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | Alanine--glyoxylate transaminase; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family; KEGG: vni:VIBNI_A3034 alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase. | 0.911 |
gcaT | gldC | VSVS12_03653 | VSVS12_04284 | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.941 |
gcaT | glyA | VSVS12_03653 | VSVS12_00907 | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.930 |
gcaT | ltaE | VSVS12_03653 | VSVS12_03603 | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | Belongs to the threonine aldolase family; KEGG: vch:VCA0765 threonine aldolase. | 0.913 |
gcaT | tdh | VSVS12_03653 | VSVS12_03654 | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.993 |
gldC | agxT | VSVS12_04284 | VSVS12_00580 | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Alanine--glyoxylate transaminase; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family; KEGG: vni:VIBNI_A3034 alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase. | 0.938 |
gldC | gcaT | VSVS12_04284 | VSVS12_03653 | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.941 |
gldC | glyA | VSVS12_04284 | VSVS12_00907 | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
gldC | ilvA | VSVS12_04284 | VSVS12_00220 | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.417 |
gldC | ltaE | VSVS12_04284 | VSVS12_03603 | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Belongs to the threonine aldolase family; KEGG: vch:VCA0765 threonine aldolase. | 0.946 |
gldC | tdh | VSVS12_04284 | VSVS12_03654 | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.451 |