KIH70641.1 protein (Salinicoccus roseus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

KIH70641.1

Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)

Predicted Functional Partners:

KIH70639.1

0.969

KIH70640.1

0.951

KIH70279.1

0.570

KIH70642.1

0.547

KIH72062.1

0.440

KIH69675.1

0.410

Your Current Organism:

Salinicoccus roseus

NCBI taxonomy Id: 45670
Other names: ATCC 49258, CCM 3516, CCUG 43291, CIP 104761, DSM 5351, JCM 14630, Micrococcus sp. CCM 168, S. roseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KIH69675.1	KIH70641.1	SN16_12680	SN16_08010	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.410
KIH70279.1	KIH70641.1	SN16_10035	SN16_08010	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.570
KIH70639.1	KIH70640.1	SN16_08000	SN16_08005	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.986
KIH70639.1	KIH70641.1	SN16_08000	SN16_08010	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.969
KIH70639.1	KIH70642.1	SN16_08000	SN16_08015	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Butanediol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.547
KIH70640.1	KIH70639.1	SN16_08005	SN16_08000	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.986
KIH70640.1	KIH70641.1	SN16_08005	SN16_08010	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.951
KIH70640.1	KIH70642.1	SN16_08005	SN16_08015	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Butanediol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.560
KIH70641.1	KIH69675.1	SN16_08010	SN16_12680	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.410
KIH70641.1	KIH70279.1	SN16_08010	SN16_10035	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.570
KIH70641.1	KIH70639.1	SN16_08010	SN16_08000	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.969
KIH70641.1	KIH70640.1	SN16_08010	SN16_08005	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.951
KIH70641.1	KIH70642.1	SN16_08010	SN16_08015	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Butanediol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.547
KIH70641.1	KIH72062.1	SN16_08010	SN16_01280	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.440
KIH70642.1	KIH70639.1	SN16_08015	SN16_08000	Butanediol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.547
KIH70642.1	KIH70640.1	SN16_08015	SN16_08005	Butanediol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.560
KIH70642.1	KIH70641.1	SN16_08015	SN16_08010	Butanediol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.547
KIH72062.1	KIH70641.1	SN16_01280	SN16_08010	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.440

Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.898

expected number of edges:

12

PPI enrichment p-value:

5.66e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006091

Generation of precursor metabolites and energy

10 of 233

1.48

2.82

9.84e-12

GO:0022900

Electron transport chain

7 of 161

1.49

2.13

3.79e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016655

Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

10 of 28

2.4

8.79

1.69e-20

GO:0048038

Quinone binding

10 of 39

2.26

7.91

9.77e-20

GO:0050136

NADH dehydrogenase (quinone) activity

8 of 25

2.36

6.85

1.26e-15

GO:0008137

NADH dehydrogenase (ubiquinone) activity

5 of 18

2.3

4.01

6.96e-09

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

10 of 879

0.91

0.99

5.13e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3104

Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

10 of 22

2.51

9.4

4.96e-21

CL:3096

Oxidoreduction-driven active transmembrane transporter activity, and Ubiquinone

11 of 57

2.14

7.59

7.54e-21

CL:3105

Quinone

6 of 12

2.55

5.85

2.47e-12

CL:3106

Quinone

5 of 6

2.77

5.35

7.63e-11

CL:3130

Quinone

3 of 6

2.55

2.59

1.44e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

sus00190

Oxidative phosphorylation

11 of 81

1.99

6.54

3.69e-20

sus01100

Metabolic pathways

11 of 1043

0.88

0.99

1.46e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030964

NADH dehydrogenase complex

6 of 15

2.45

5.3

2.21e-11

GOCC:0045272

Plasma membrane respiratory chain complex I

2 of 7

2.31

1.35

0.0031

GOCC:0016020

Membrane

10 of 1242

0.76

0.73

7.07e-06

GOCC:0005886

Plasma membrane

6 of 636

0.83

0.62

0.0039

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1278

Translocase

11 of 26

2.48

10.6

1.12e-24

KW-0874

Quinone

10 of 19

2.57

10.29

1.02e-22

KW-0830

Ubiquinone

10 of 23

2.49

9.77

3.15e-22

KW-0520

NAD

10 of 61

2.07

6.65

1.17e-18

KW-0997

Cell inner membrane

10 of 86

1.92

5.6

2.29e-17

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00507

NADH-ubiquinone/plastoquinone oxidoreductase, chain 3

2 of 2

2.85

1.11

0.0099

PF00346

Respiratory-chain NADH dehydrogenase, 49 Kd subunit

2 of 2

2.85

1.11

0.0099

PF00329

Respiratory-chain NADH dehydrogenase, 30 Kd subunit

2 of 2

2.85

1.11

0.0099

PF00146

NADH dehydrogenase

2 of 2

2.85

1.11

0.0099

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR038430

NADH:ubiquinone oxidoreductase, subunit 3 superfamily

2 of 2

2.85

0.9

0.0238

IPR037232

NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily

2 of 2

2.85

0.9

0.0238

IPR023043

NAD(P)H-quinone oxidoreductase subunit 3, bacterial/plastid

2 of 2

2.85

0.9

0.0238

IPR022885

NAD(P)H-quinone oxidoreductase subunit D/H

2 of 2

2.85

0.9

0.0238

IPR020396

NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site

2 of 2

2.85

0.9

0.0238

(more ...)

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