Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EFL22348.1Citrate (Pro-3S)-lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. (324 aa)    
Predicted Functional Partners:
EFL22349.1
MaoC domain protein.
 
 
 0.977
EFL22347.1
methylmalonyl-CoA mutase.
 
   
 0.925
EFL28911.1
Putative citrate lyase, beta subunit.
 
  
 0.919
EFL22350.1
acyl-CoA dehydrogenase.
  
 
  0.905
EFL22346.1
crotonyl-CoA reductase.
 
  
  0.880
EFL23292.1
Oxoglutarate dehydrogenase (succinyl-transferring), E1 component.
  
 
 0.880
EFL22456.1
Malate synthase A; Belongs to the malate synthase family.
    
 0.864
EFL23140.1
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
     
 0.864
EFL25490.1
propionyl-CoA carboxylase, beta subunit.
  
 
 0.862
acsA
acetate-CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
    
  0.857
Your Current Organism:
Streptomyces himastatinicus
NCBI taxonomy Id: 457427
Other names: S. himastatinicus ATCC 53653, Streptomyces himastatinicus ATCC 53653, Streptomyces himastatinicus str. ATCC 53653, Streptomyces himastatinicus strain ATCC 53653, Streptomyces hygroscopicus ATCC 53653
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