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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
Score
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (311 aa)    
Predicted Functional Partners:
EFL24219.1
Porphobilinogen synthase; Belongs to the ALAD family.
 
 0.998
EFL24220.1
uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase.
 0.998
EFL21916.1
uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
 
 0.995
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 0.990
EFL25669.1
uroporphyrinogen-III synthase domain protein.
  
 0.986
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.959
hemL
Glutamate-1-semialdehyde-2,1-aminomutase.
 
  
 0.924
hemC-2
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
  
 
0.879
EFL20702.1
precorrin-3B C(17)-methyltransferase; Truncated CDS; unextendable partial coding region.
 
  
 0.768
EFL27758.1
Putative glutamate-1-semialdehyde-2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
  
 0.766
Your Current Organism:
Streptomyces himastatinicus
NCBI taxonomy Id: 457427
Other names: S. himastatinicus ATCC 53653, Streptomyces himastatinicus ATCC 53653, Streptomyces himastatinicus str. ATCC 53653, Streptomyces himastatinicus strain ATCC 53653, Streptomyces hygroscopicus ATCC 53653
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