Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EFL22681.1Homocysteine S-methyltransferase. (306 aa)    
Predicted Functional Partners:
EFL27376.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
   
 
 0.915
EFL23614.1
Cystathionine gamma-synthase.
 
 
 0.913
EFL24725.1
Cys/Met metabolism PLP-dependent enzyme family protein.
 
 
 0.909
EFL21501.1
Pyridoxal-phosphate dependent enzyme.
  
  
 0.885
EFL23245.1
Homoserine dehydrogenase.
   
 
 0.883
metE
5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
   
 
 0.882
EFL25531.1
Cystathionine beta-synthase.
     
 0.862
EFL23610.1
Threonine ammonia-lyase.
     
 0.858
EFL27060.1
Putative threonine dehydratase, PLP-dependent.
     
 0.858
EFL28551.1
Pyridoxal-phosphate dependent enzyme.
     
 0.858
Your Current Organism:
Streptomyces himastatinicus
NCBI taxonomy Id: 457427
Other names: S. himastatinicus ATCC 53653, Streptomyces himastatinicus ATCC 53653, Streptomyces himastatinicus str. ATCC 53653, Streptomyces himastatinicus strain ATCC 53653, Streptomyces hygroscopicus ATCC 53653
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