Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EFL23115.1Conserved hypothetical protein. (388 aa)    
Predicted Functional Partners:
guaA
GMP synthase (Glutamine amidotransferase); Catalyzes the synthesis of GMP from XMP.
  
 
  0.726
EFL24220.1
uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase.
   
 
  0.605
EFL25380.1
Putative regulator of sigma factor.
  
     0.577
EFL24781.1
Integrase; Truncated CDS.
  
     0.555
EFL27820.1
Putative regulator of sigma factor.
  
     0.515
EFL24785.1
Integrase; Unextendable partial coding region; Belongs to the 'phage' integrase family.
  
     0.511
EFL26283.1
Nitrite reductase [NAD(P)H], small subunit.
 
     0.496
EFL25734.1
RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.481
EFL25721.1
Putative nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
    
  0.479
EFL26687.1
Conserved hypothetical protein.
  
     0.475
Your Current Organism:
Streptomyces himastatinicus
NCBI taxonomy Id: 457427
Other names: S. himastatinicus ATCC 53653, Streptomyces himastatinicus ATCC 53653, Streptomyces himastatinicus str. ATCC 53653, Streptomyces himastatinicus strain ATCC 53653, Streptomyces hygroscopicus ATCC 53653
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.