Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
kuKu protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (357 aa)    
Predicted Functional Partners:
EFL23869.1
DNA polymerase LigD, polymerase domain protein.
 
  
 0.984
EFL23867.1
DNA ligase, ATP-dependent.
 
  
 0.973
EFL21040.1
DNA polymerase LigD, polymerase domain protein.
 
  
 0.911
EFL24579.1
DNA polymerase LigD, polymerase domain protein.
 
  
 0.911
EFL21039.1
Putative DNA ligase.
 
  
 0.894
EFL24576.1
DNA ligase I, ATP-dependent (Dnl1); Truncated CDS.
 
  
 0.649
EFL22122.1
G6PDH family F420-dependent oxidoreductase.
     
  0.627
EFL22317.1
F420-dependent glucose-6-phosphate dehydrogenase FGD1.
     
  0.627
EFL23866.1
Conserved hypothetical protein.
       0.448
Your Current Organism:
Streptomyces himastatinicus
NCBI taxonomy Id: 457427
Other names: S. himastatinicus ATCC 53653, Streptomyces himastatinicus ATCC 53653, Streptomyces himastatinicus str. ATCC 53653, Streptomyces himastatinicus strain ATCC 53653, Streptomyces hygroscopicus ATCC 53653
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