Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
EFL23980.1Two-component system, regulatory protein. (203 aa)    
Predicted Functional Partners:
EFL22809.1
Sensor histidine kinase/response regulator.
  
 0.932
EFL27138.1
Sensor histidine kinase/response regulator.
   
 0.871
EFL23979.1
RNA polymerase sigma-70 factor, ECF subfamily.
  
    0.731
whiB-4
WhiB-related protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
     
 0.688
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
       0.679
EFL27851.1
Response regulator, two-component system.
  
     0.671
EFL21514.1
Putative signal transduction histidine kinase.
  
  0.649
EFL27190.1
Putative two-component system sensor kinase; Truncated CDS.
 
  0.645
EFL25025.1
Histidine protein kinase sensor protein (putative).
  
   0.628
EFL22742.1
Sensor kinase, two-component system.
  
  0.594
Your Current Organism:
Streptomyces himastatinicus
NCBI taxonomy Id: 457427
Other names: S. himastatinicus ATCC 53653, Streptomyces himastatinicus ATCC 53653, Streptomyces himastatinicus str. ATCC 53653, Streptomyces himastatinicus strain ATCC 53653, Streptomyces hygroscopicus ATCC 53653
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