Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
htpX-2Protease HTPX; Belongs to the peptidase M48B family. (307 aa)    
Predicted Functional Partners:
EFL24748.1
Conserved hypothetical protein.
 
     0.957
EFL24745.1
Conserved hypothetical protein.
       0.770
EFL24746.1
Cof protein.
  
    0.724
ftsH
Putative cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.720
EFL25903.1
Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family.
  
    0.690
EFL22703.1
Nucleic acid binding, OB-fold, tRNA/helicase-type.
   
  
 0.607
EFL20831.1
Probable bifunctional P-450/NADPH-P450 reductase 1.
    
   0.581
EFL28515.1
Bifunctional P-450/NADPH-P450 reductase (Cytochrome P450(BM-3))(P450BM-3).
    
   0.581
EFL24749.1
Conserved hypothetical protein.
 
     0.572
secY
Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
   
 
 0.559
Your Current Organism:
Streptomyces himastatinicus
NCBI taxonomy Id: 457427
Other names: S. himastatinicus ATCC 53653, Streptomyces himastatinicus ATCC 53653, Streptomyces himastatinicus str. ATCC 53653, Streptomyces himastatinicus strain ATCC 53653, Streptomyces hygroscopicus ATCC 53653
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