Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mshA1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. (453 aa)    
Predicted Functional Partners:
mshB
1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D- glucopyranoside deacetylase; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.
 
 
 0.946
mshD
Mycothiol biosynthesis acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
  
   
 0.913
EFL25109.1
Conserved hypothetical protein.
 
     0.913
mca
Mycothiol conjugate amidase Mca; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily.
  
 
 0.909
EFL27361.1
cysteine-1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase.
  
   
 0.898
EFL25107.1
Conserved hypothetical protein.
 
    0.813
EFL23088.1
Alpha-glucan phosphorylase.
  
 0.781
EFL24695.1
Inositol 1-phosphate synthase.
  
  
 0.745
EFL22577.1
4-alpha-D-((1-4)-alpha-D-glucano)trehalose trehalohydrolase; Truncated CDS; Belongs to the glycosyl hydrolase 13 family.
   
 0.734
EFL25111.1
Conserved hypothetical protein.
       0.732
Your Current Organism:
Streptomyces himastatinicus
NCBI taxonomy Id: 457427
Other names: S. himastatinicus ATCC 53653, Streptomyces himastatinicus ATCC 53653, Streptomyces himastatinicus str. ATCC 53653, Streptomyces himastatinicus strain ATCC 53653, Streptomyces hygroscopicus ATCC 53653
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