A0A1D6EIJ8 protein (Zea mays) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

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[Homology]

Score

A0A1D6EIJ8

Uncharacterized protein. (410 aa)

Predicted Functional Partners:

Umc1614

0.521

A0A1D6H7X1

0.517

C0P8W9_MAIZE

0.517

A0A1D6MFT1

0.434

A0A1D6PU88

0.433

A0A096RF35

0.432

B6TXB0_MAIZE

0.432

rps14

0.432

Si945024a11

0.431

A0A1D6GXW0

0.425

Your Current Organism:

Zea mays

NCBI taxonomy Id: 4577
Other names: Z. mays, Zea mays L., Zea mays var. japonica, maize

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A096RF35	A0A1D6EIJ8	A0A096RF35	A0A1D6EIJ8	Mitochondrial 28S ribosomal protein S29-related.	Uncharacterized protein.	0.432
A0A096RF35	A0A1D6GXW0	A0A096RF35	A0A1D6GXW0	Mitochondrial 28S ribosomal protein S29-related.	Ribosomal protein S5 family protein; Belongs to the universal ribosomal protein uS5 family.	0.999
A0A096RF35	A0A1D6MFT1	A0A096RF35	A0A1D6MFT1	Mitochondrial 28S ribosomal protein S29-related.	Translation elongation factor EF1B/ribosomal protein S6 family protein.	0.987
A0A096RF35	B6TXB0_MAIZE	A0A096RF35	B6TXB0	Mitochondrial 28S ribosomal protein S29-related.	Ribosomal protein S24/S35 mitochondrial.	0.996
A0A096RF35	rps14	A0A096RF35	P08527	Mitochondrial 28S ribosomal protein S29-related.	30S ribosomal protein S14, chloroplastic; Binds 16S rRNA, required for the assembly of 30S particles.	0.990
A0A1D6EIJ8	A0A096RF35	A0A1D6EIJ8	A0A096RF35	Uncharacterized protein.	Mitochondrial 28S ribosomal protein S29-related.	0.432
A0A1D6EIJ8	A0A1D6GXW0	A0A1D6EIJ8	A0A1D6GXW0	Uncharacterized protein.	Ribosomal protein S5 family protein; Belongs to the universal ribosomal protein uS5 family.	0.425
A0A1D6EIJ8	A0A1D6H7X1	A0A1D6EIJ8	A0A1D6H7X1	Uncharacterized protein.	High mobility group B protein 15.	0.517
A0A1D6EIJ8	A0A1D6MFT1	A0A1D6EIJ8	A0A1D6MFT1	Uncharacterized protein.	Translation elongation factor EF1B/ribosomal protein S6 family protein.	0.434
A0A1D6EIJ8	A0A1D6PU88	A0A1D6EIJ8	A0A1D6PU88	Uncharacterized protein.	Tetratricopeptide repeat (TPR)-containing protein.	0.433
A0A1D6EIJ8	B6TXB0_MAIZE	A0A1D6EIJ8	B6TXB0	Uncharacterized protein.	Ribosomal protein S24/S35 mitochondrial.	0.432
A0A1D6EIJ8	C0P8W9_MAIZE	A0A1D6EIJ8	C0P8W9	Uncharacterized protein.	High mobility group B protein 15.	0.517
A0A1D6EIJ8	Si945024a11	A0A1D6EIJ8	C0PMW7	Uncharacterized protein.	Serine/threonine-protein kinase ATG1t.	0.431
A0A1D6EIJ8	Umc1614	A0A1D6EIJ8	A0A1D6LWT4	Uncharacterized protein.	Chromatin structure-remodeling complex protein SYD.	0.521
A0A1D6EIJ8	rps14	A0A1D6EIJ8	P08527	Uncharacterized protein.	30S ribosomal protein S14, chloroplastic; Binds 16S rRNA, required for the assembly of 30S particles.	0.432
A0A1D6GXW0	A0A096RF35	A0A1D6GXW0	A0A096RF35	Ribosomal protein S5 family protein; Belongs to the universal ribosomal protein uS5 family.	Mitochondrial 28S ribosomal protein S29-related.	0.999
A0A1D6GXW0	A0A1D6EIJ8	A0A1D6GXW0	A0A1D6EIJ8	Ribosomal protein S5 family protein; Belongs to the universal ribosomal protein uS5 family.	Uncharacterized protein.	0.425
A0A1D6GXW0	A0A1D6MFT1	A0A1D6GXW0	A0A1D6MFT1	Ribosomal protein S5 family protein; Belongs to the universal ribosomal protein uS5 family.	Translation elongation factor EF1B/ribosomal protein S6 family protein.	0.998
A0A1D6GXW0	B6TXB0_MAIZE	A0A1D6GXW0	B6TXB0	Ribosomal protein S5 family protein; Belongs to the universal ribosomal protein uS5 family.	Ribosomal protein S24/S35 mitochondrial.	0.999
A0A1D6GXW0	rps14	A0A1D6GXW0	P08527	Ribosomal protein S5 family protein; Belongs to the universal ribosomal protein uS5 family.	30S ribosomal protein S14, chloroplastic; Binds 16S rRNA, required for the assembly of 30S particles.	0.997

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Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.933

expected number of edges:

10

PPI enrichment p-value:

1.88e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006665

Sphingolipid metabolic process

7 of 109

2.33

6.08

1.14e-12

GO:0030148

Sphingolipid biosynthetic process

6 of 57

2.55

6.05

1.11e-11

GO:0046512

Sphingosine biosynthetic process

4 of 9

3.17

5.23

2.31e-09

GO:0006672

Ceramide metabolic process

5 of 50

2.52

4.89

2.01e-09

GO:0030149

Sphingolipid catabolic process

4 of 43

2.49

3.78

2.46e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001727

Lipid kinase activity

3 of 4

3.4

3.58

1.47e-06

GO:0017040

N-acylsphingosine amidohydrolase activity

3 of 9

3.05

3.24

4.62e-06

GO:0003951

NAD+ kinase activity

3 of 19

2.72

2.79

2.16e-05

GO:0071633

Dihydroceramidase activity

2 of 2

3.52

2.19

0.00028

GO:0102121

Ceramidase activity

2 of 6

3.05

1.84

0.0010

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:34972

Sphingolipid metabolism

6 of 50

2.6

6.19

8.49e-12

CL:34973

Sphingolipid metabolism

5 of 37

2.65

5.39

3.95e-10

CL:34974

Sphingolipid metabolism

4 of 31

2.63

4.01

1.35e-07

CL:34977

Ceramide biosynthetic process, and N-acylsphingosine amidohydrolase activity

3 of 16

2.8

2.97

1.15e-05

CL:34999

N-acylsphingosine amidohydrolase activity, and Ceramide kinase activity

2 of 5

3.13

1.88

0.00086

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lak00600

Sphingolipid metabolism

5 of 77

2.34

4.69

1.70e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-428157

Sphingolipid metabolism

7 of 142

2.22

5.72

1.56e-12

MAP-1660662

Glycosphingolipid metabolism

4 of 107

2.1

2.71

8.72e-06

MAP-1660661

Sphingolipid de novo biosynthesis

3 of 35

2.46

2.52

4.95e-05

MAP-556833

Metabolism of lipids

7 of 1070

1.34

1.8

8.82e-07

MAP-1430728

Metabolism

7 of 3499

0.82

0.67

0.0013

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030173

Integral component of Golgi membrane

2 of 20

2.52

0.99

0.0236

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05875

Ceramidase

2 of 2

3.52

1.83

0.0011

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001206

Diacylglycerol kinase, catalytic domain

3 of 11

2.96

2.65

4.34e-05

IPR017438

Inorganic polyphosphate/ATP-NAD kinase, N-terminal

3 of 13

2.89

2.64

4.34e-05

IPR016064

NAD kinase/diacylglycerol kinase-like domain superfamily

3 of 13

2.89

2.64

4.34e-05

IPR045363

Ceramide kinase, C-terminal domain

2 of 2

3.52

1.91

0.00080

IPR008901

Alkaline ceramidase

2 of 2

3.52

1.91

0.00080

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00046

Diacylglycerol kinase catalytic domain (presumed)

2 of 10

2.82

1.49

0.0037

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