Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mvaA_1Hydroxymethylglutaryl CoA reductase; Belongs to the HMG-CoA reductase family. (428 aa)    
Predicted Functional Partners:
Lrub_0272
Mevalonate kinase.
 
 0.976
pksG
Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG.
 
 0.972
fni
Isopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
   
 0.963
Lrub_0259
Hypothetical protein.
  
 0.903
Lrub_0271
Mevalonate diphosphate decarboxylase.
 
 
 0.888
Lrub_1762
Mevalonate kinase.
 
 0.854
idi
Isopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
  
 
 0.767
Lrub_0263
Hypothetical protein.
       0.714
Lrub_0262
Hypothetical protein.
       0.675
Lrub_0264
ABC transporter permease.
       0.674
Your Current Organism:
Legionella rubrilucens
NCBI taxonomy Id: 458
Other names: ATCC 35304, CCUG 29671, CIP 103848, DSM 11884, JCM 7565, L. rubrilucens, NCTC 11987, strain WA-270A-C2
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