Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
fniIsopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (342 aa)    
Predicted Functional Partners:
mvaA_1
Hydroxymethylglutaryl CoA reductase; Belongs to the HMG-CoA reductase family.
   
 0.963
Lrub_0271
Mevalonate diphosphate decarboxylase.
 
  
 0.962
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.912
Lrub_0259
Hypothetical protein.
    
 0.907
Lrub_0272
Mevalonate kinase.
 
  
 0.871
Lrub_0899
Geranyltranstransferase; Belongs to the FPP/GGPP synthase family.
  
 
 0.868
Lrub_1762
Mevalonate kinase.
 
  
 0.830
idi
Isopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
    
 0.829
pksG
Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG.
 
 
 0.825
korA
2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
    
 0.799
Your Current Organism:
Legionella rubrilucens
NCBI taxonomy Id: 458
Other names: ATCC 35304, CCUG 29671, CIP 103848, DSM 11884, JCM 7565, L. rubrilucens, NCTC 11987, strain WA-270A-C2
Server load: medium (42%) [HD]