| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Lrub_2224 | glyA | Lrub_2224 | Lrub_1071 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.945 |
| Lrub_2224 | ilvA | Lrub_2224 | Lrub_0495 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | L-threonine dehydratase biosynthetic IlvA. | 0.885 |
| Lrub_2224 | lysAC | Lrub_2224 | Lrub_1101 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.625 |
| Lrub_2224 | metB | Lrub_2224 | Lrub_1260 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Cystathionine beta-lyase. | 0.863 |
| Lrub_2224 | trpA | Lrub_2224 | Lrub_1338 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.859 |
| Lrub_2224 | trpB | Lrub_2224 | Lrub_1337 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.839 |
| dlpA | edd | Lrub_2357 | Lrub_1377 | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.768 |
| dlpA | ilvA | Lrub_2357 | Lrub_0495 | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | L-threonine dehydratase biosynthetic IlvA. | 0.851 |
| dlpA | lysAC | Lrub_2357 | Lrub_1101 | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | Bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.720 |
| dlpA | trpA | Lrub_2357 | Lrub_1338 | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.553 |
| dlpA | trpB | Lrub_2357 | Lrub_1337 | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.458 |
| edd | dlpA | Lrub_1377 | Lrub_2357 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | 0.768 |
| edd | ilvA | Lrub_1377 | Lrub_0495 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | L-threonine dehydratase biosynthetic IlvA. | 0.861 |
| edd | lysAC | Lrub_1377 | Lrub_1101 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.728 |
| glyA | Lrub_2224 | Lrub_1071 | Lrub_2224 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.945 |
| glyA | ilvA | Lrub_1071 | Lrub_0495 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-threonine dehydratase biosynthetic IlvA. | 0.876 |
| glyA | ltaE | Lrub_1071 | Lrub_1742 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Low specificity L-threonine aldolase. | 0.905 |
| glyA | lysAC | Lrub_1071 | Lrub_1101 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.805 |
| glyA | trpA | Lrub_1071 | Lrub_1338 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.873 |
| glyA | trpB | Lrub_1071 | Lrub_1337 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.873 |
