Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)    
Predicted Functional Partners:
prpC
2-methylcitrate synthase; Belongs to the citrate synthase family.
  
 0.984
gltA
Citrate synthase; Belongs to the citrate synthase family.
  
 0.984
icd
Isocitrate dehydrogenase.
  
 0.978
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.976
korA
2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
  
 
 0.974
Lrub_2102
Ferredoxin II (4Fe-4S); Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
  
 
 0.942
pykA
Pyruvate kinase II; Belongs to the pyruvate kinase family.
  
 0.932
acnA
Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.930
Lrub_0834
Oxaloacetate decarboxylase subunit alpha.
    
 0.922
htpB
Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 0.922
Your Current Organism:
Legionella rubrilucens
NCBI taxonomy Id: 458
Other names: ATCC 35304, CCUG 29671, CIP 103848, DSM 11884, JCM 7565, L. rubrilucens, NCTC 11987, strain WA-270A-C2
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