Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Lrub_2046Phenylalanine-4-hydroxylase. (272 aa)    
Predicted Functional Partners:
Lrub_2185
Pterin-4-alpha-carbinolamine dehydratase.
 
 0.996
lly
4-hydroxyphenylpyruvate dioxygenase.
 
  
 0.956
hmgA
Homogentisate 1,2-dioxygenase.
 
  
 0.934
hisC
Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase).
     
 0.874
hisC-2
Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
     
 0.874
Lrub_2713
Aspartate aminotransferase.
   
 
 0.856
folA
Dihydrofolate reductase FolA; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.843
Lrub_2554
Pteridine reductase.
    
  0.840
ubiC
4-hydroxybenzoate synthetase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family.
     
  0.839
Lrub_0666
Glutathione S-transferase (maleylacetoacetate isomerase).
 
  
 0.793
Your Current Organism:
Legionella rubrilucens
NCBI taxonomy Id: 458
Other names: ATCC 35304, CCUG 29671, CIP 103848, DSM 11884, JCM 7565, L. rubrilucens, NCTC 11987, strain WA-270A-C2
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