| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| adk | guaA | Lrub_0587 | Lrub_0250 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.908 |
| adk | purA | Lrub_0587 | Lrub_0860 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.749 |
| adk | purB | Lrub_0587 | Lrub_2236 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.952 |
| adk | purC | Lrub_0587 | Lrub_1945 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Phosphoribosylamidoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.430 |
| adk | purH | Lrub_0587 | Lrub_0829 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.574 |
| adk | purM | Lrub_0587 | Lrub_1943 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Phosphoribosylformylglycinamidine cyclo ligase. | 0.544 |
| guaA | adk | Lrub_0250 | Lrub_0587 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.908 |
| guaA | purA | Lrub_0250 | Lrub_0860 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.960 |
| guaA | purB | Lrub_0250 | Lrub_2236 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.942 |
| guaA | purC | Lrub_0250 | Lrub_1945 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylamidoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.842 |
| guaA | purD | Lrub_0250 | Lrub_1947 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylamine-glycine ligase; Belongs to the GARS family. | 0.954 |
| guaA | purE | Lrub_0250 | Lrub_1949 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.819 |
| guaA | purF | Lrub_0250 | Lrub_1946 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.927 |
| guaA | purH | Lrub_0250 | Lrub_0829 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.974 |
| guaA | purM | Lrub_0250 | Lrub_1943 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformylglycinamidine cyclo ligase. | 0.855 |
| guaA | purN | Lrub_0250 | Lrub_1948 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.807 |
| purA | adk | Lrub_0860 | Lrub_0587 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.749 |
| purA | guaA | Lrub_0860 | Lrub_0250 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.960 |
| purA | purB | Lrub_0860 | Lrub_2236 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.997 |
| purA | purC | Lrub_0860 | Lrub_1945 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Phosphoribosylamidoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.988 |