Lrub_2518 protein (Legionella rubrilucens) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

Lrub_2518

Putative phosphotransferase. (351 aa)

Predicted Functional Partners:

Lrub_2519

0.996

glmU_2

0.862

lptD

0.825

folA

0.674

pdxA

0.674

surA-2

0.674

Lrub_0974

0.662

murB

0.545

murA

0.520

Lrub_2405

0.483

Your Current Organism:

Legionella rubrilucens

NCBI taxonomy Id: 458
Other names: ATCC 35304, CCUG 29671, CIP 103848, DSM 11884, JCM 7565, L. rubrilucens, NCTC 11987, strain WA-270A-C2

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lrub_0974	Lrub_2518	Lrub_0974	Lrub_2518	Hydrolase.	Putative phosphotransferase.	0.662
Lrub_2405	Lrub_2518	Lrub_2405	Lrub_2518	Hypothetical protein.	Putative phosphotransferase.	0.483
Lrub_2405	glmU_2	Lrub_2405	Lrub_2784	Hypothetical protein.	Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.421
Lrub_2518	Lrub_0974	Lrub_2518	Lrub_0974	Putative phosphotransferase.	Hydrolase.	0.662
Lrub_2518	Lrub_2405	Lrub_2518	Lrub_2405	Putative phosphotransferase.	Hypothetical protein.	0.483
Lrub_2518	Lrub_2519	Lrub_2518	Lrub_2519	Putative phosphotransferase.	Mannose-1-phosphate guanyltransferase.	0.996
Lrub_2518	folA	Lrub_2518	Lrub_2514	Putative phosphotransferase.	Dihydrofolate reductase FolA; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	0.674
Lrub_2518	glmU_2	Lrub_2518	Lrub_2784	Putative phosphotransferase.	Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.862
Lrub_2518	lptD	Lrub_2518	Lrub_2517	Putative phosphotransferase.	Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.	0.825
Lrub_2518	murA	Lrub_2518	Lrub_1234	Putative phosphotransferase.	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.	0.520
Lrub_2518	murB	Lrub_2518	Lrub_1733	Putative phosphotransferase.	UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation.	0.545
Lrub_2518	pdxA	Lrub_2518	Lrub_2515	Putative phosphotransferase.	4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).	0.674
Lrub_2518	surA-2	Lrub_2518	Lrub_2516	Putative phosphotransferase.	Peptidyl-prolyl cis-trans isomerase D; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.	0.674
Lrub_2519	Lrub_2518	Lrub_2519	Lrub_2518	Mannose-1-phosphate guanyltransferase.	Putative phosphotransferase.	0.996
Lrub_2519	folA	Lrub_2519	Lrub_2514	Mannose-1-phosphate guanyltransferase.	Dihydrofolate reductase FolA; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	0.743
Lrub_2519	glmU_2	Lrub_2519	Lrub_2784	Mannose-1-phosphate guanyltransferase.	Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.584
Lrub_2519	lptD	Lrub_2519	Lrub_2517	Mannose-1-phosphate guanyltransferase.	Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.	0.802
Lrub_2519	murA	Lrub_2519	Lrub_1234	Mannose-1-phosphate guanyltransferase.	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.	0.851
Lrub_2519	murB	Lrub_2519	Lrub_1733	Mannose-1-phosphate guanyltransferase.	UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation.	0.839
Lrub_2519	pdxA	Lrub_2519	Lrub_2515	Mannose-1-phosphate guanyltransferase.	4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).	0.674