Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
poxBPyruvate dehydrogenase; Belongs to the TPP enzyme family. (573 aa)    
Predicted Functional Partners:
ilvA
L-threonine dehydratase biosynthetic IlvA.
  
 0.837
korA
2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
    
 0.827
dlpA
DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein).
  
 0.814
mao2
Malate oxidoreductase.
   
 0.799
sfcA_1
Malate dehydrogenase.
   
 0.799
sfcA_2
Malate dehydrogenase.
   
 0.799
pykA
Pyruvate kinase II; Belongs to the pyruvate kinase family.
  
 0.787
Lrub_0449
Alcohol dehydrogenase; Belongs to the aldehyde dehydrogenase family.
   
 0.783
ppsA
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
    
 0.779
acsB
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
     
 0.775
Your Current Organism:
Legionella rubrilucens
NCBI taxonomy Id: 458
Other names: ATCC 35304, CCUG 29671, CIP 103848, DSM 11884, JCM 7565, L. rubrilucens, NCTC 11987, strain WA-270A-C2
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