| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gcvH | gcvP2 | MCCL_0536 | MCCL_1179 | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | Glycine cleavage system P protein subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.999 |
| gcvH | gcvT1 | MCCL_0536 | MCCL_1181 | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
| gcvH | glyA | MCCL_0536 | MCCL_1766 | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.963 |
| gcvH | odhA | MCCL_0536 | MCCL_1064 | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | 2-oxoglutarate dehydrogenase, E1 component homolog; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). | 0.834 |
| gcvH | odhB | MCCL_0536 | MCCL_1063 | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | Dihydrolipoamide acetyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.703 |
| gcvH | pdhA | MCCL_0536 | MCCL_0710 | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). | 0.746 |
| gcvH | pdhB | MCCL_0536 | MCCL_0711 | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | Pyruvate dehydrogenase E1 component beta subunit. | 0.781 |
| gcvH | pdhC | MCCL_0536 | MCCL_0712 | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | Dihydrolipoamide acetyltransferase subunit E2. | 0.703 |
| gcvH | pdhD | MCCL_0536 | MCCL_0713 | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | Dihydrolipoamide dehydrogenase subunit E3. | 0.976 |
| gcvP2 | gcvH | MCCL_1179 | MCCL_0536 | Glycine cleavage system P protein subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | 0.999 |
| gcvP2 | gcvT1 | MCCL_1179 | MCCL_1181 | Glycine cleavage system P protein subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
| gcvP2 | glyA | MCCL_1179 | MCCL_1766 | Glycine cleavage system P protein subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.974 |
| gcvP2 | odhA | MCCL_1179 | MCCL_1064 | Glycine cleavage system P protein subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 2-oxoglutarate dehydrogenase, E1 component homolog; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). | 0.433 |
| gcvP2 | pdhD | MCCL_1179 | MCCL_0713 | Glycine cleavage system P protein subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | Dihydrolipoamide dehydrogenase subunit E3. | 0.918 |
| gcvT1 | gcvH | MCCL_1181 | MCCL_0536 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | 0.999 |
| gcvT1 | gcvP2 | MCCL_1181 | MCCL_1179 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Glycine cleavage system P protein subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.999 |
| gcvT1 | glyA | MCCL_1181 | MCCL_1766 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
| gcvT1 | odhA | MCCL_1181 | MCCL_1064 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 2-oxoglutarate dehydrogenase, E1 component homolog; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). | 0.586 |
| gcvT1 | pdhB | MCCL_1181 | MCCL_0711 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Pyruvate dehydrogenase E1 component beta subunit. | 0.508 |
| gcvT1 | pdhD | MCCL_1181 | MCCL_0713 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Dihydrolipoamide dehydrogenase subunit E3. | 0.932 |
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