node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MCCL_1303 | MCCL_1305 | MCCL_1303 | MCCL_1305 | Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Conserved hypothetical protein; Similar to HemA concentration negative effector HemX. | 0.908 |
MCCL_1303 | MCCL_1338 | MCCL_1303 | MCCL_1338 | Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Conserved hypothetical protein; Similar to uroporphyrin-III C-methyltransferase. | 0.972 |
MCCL_1303 | MCCL_1341 | MCCL_1303 | MCCL_1341 | Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Conserved hypothetical protein; Similar to siroheme synthase. | 0.562 |
MCCL_1303 | engB | MCCL_1303 | MCCL_1307 | Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Conserved hypothetical protein; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | 0.572 |
MCCL_1303 | hemA | MCCL_1303 | MCCL_1306 | Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase homolog; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.962 |
MCCL_1303 | hemB | MCCL_1303 | MCCL_1302 | Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.989 |
MCCL_1303 | hemC | MCCL_1303 | MCCL_1304 | Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase homolog; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
MCCL_1303 | hemE | MCCL_1303 | MCCL_1550 | Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.937 |
MCCL_1303 | hemL | MCCL_1303 | MCCL_1301 | Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.960 |
MCCL_1303 | hemL2 | MCCL_1303 | MCCL_1594 | Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde aminotransferase. | 0.754 |
MCCL_1305 | MCCL_1303 | MCCL_1305 | MCCL_1303 | Conserved hypothetical protein; Similar to HemA concentration negative effector HemX. | Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.908 |
MCCL_1305 | MCCL_1338 | MCCL_1305 | MCCL_1338 | Conserved hypothetical protein; Similar to HemA concentration negative effector HemX. | Conserved hypothetical protein; Similar to uroporphyrin-III C-methyltransferase. | 0.402 |
MCCL_1305 | engB | MCCL_1305 | MCCL_1307 | Conserved hypothetical protein; Similar to HemA concentration negative effector HemX. | Conserved hypothetical protein; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | 0.593 |
MCCL_1305 | hemA | MCCL_1305 | MCCL_1306 | Conserved hypothetical protein; Similar to HemA concentration negative effector HemX. | glutamyl-tRNA reductase homolog; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.922 |
MCCL_1305 | hemB | MCCL_1305 | MCCL_1302 | Conserved hypothetical protein; Similar to HemA concentration negative effector HemX. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.820 |
MCCL_1305 | hemC | MCCL_1305 | MCCL_1304 | Conserved hypothetical protein; Similar to HemA concentration negative effector HemX. | Porphobilinogen deaminase homolog; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.898 |
MCCL_1305 | hemL | MCCL_1305 | MCCL_1301 | Conserved hypothetical protein; Similar to HemA concentration negative effector HemX. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.804 |
MCCL_1338 | MCCL_1303 | MCCL_1338 | MCCL_1303 | Conserved hypothetical protein; Similar to uroporphyrin-III C-methyltransferase. | Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.972 |
MCCL_1338 | MCCL_1305 | MCCL_1338 | MCCL_1305 | Conserved hypothetical protein; Similar to uroporphyrin-III C-methyltransferase. | Conserved hypothetical protein; Similar to HemA concentration negative effector HemX. | 0.402 |
MCCL_1338 | MCCL_1341 | MCCL_1338 | MCCL_1341 | Conserved hypothetical protein; Similar to uroporphyrin-III C-methyltransferase. | Conserved hypothetical protein; Similar to siroheme synthase. | 0.998 |