STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MCCL_1338Conserved hypothetical protein; Similar to uroporphyrin-III C-methyltransferase. (334 aa)    
Predicted Functional Partners:
MCCL_1341
Conserved hypothetical protein; Similar to siroheme synthase.
 
 
 0.998
hemC
Porphobilinogen deaminase homolog; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.989
MCCL_1303
Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.972
nasE
Nitrite reductase small subunit.
 
  
 0.970
MCCL_1342
Conserved hypothetical protein; Similar to transcriptional regulator NirR.
 
  
 0.967
nasD
Nitrite reductase large subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
 0.963
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.934
hemB
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
  
 0.889
hemA
glutamyl-tRNA reductase homolog; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.799
MCCL_0271
Conserved hypothetical protein; Similar to functionally unknown protein.
  
  
 0.730
Your Current Organism:
Macrococcus caseolyticus
NCBI taxonomy Id: 458233
Other names: M. caseolyticus JCSC5402, Macrococcus caseolyticus JCSC5402, Macrococcus caseolyticus str. JCSC5402, Macrococcus caseolyticus strain JCSC5402
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