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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MCCL_1599A/G-specific adenine glycosylase homolog; Adenine glycosylase active on G-A mispairs. (344 aa)    
Predicted Functional Partners:
MCCL_1600
Conserved hypothetical protein; Similar to functionally unknown protein.
       0.713
MCCL_1598
Conserved hypothetical protein; Similar to functionally unknown protein; Belongs to the UPF0374 family.
       0.703
dnaN
DNA polymerase III beta chain, sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is requir [...]
   
 
 0.596
rpoD
DNA-dependent DNA polymerase beta chain.
    
 
 0.471
polA
DNA polymerase I homolog; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
  
 0.452
MCCL_1273
Conserved hypothetical protein; Similar to single-strand DNA-specific exonuclease.
      
 0.450
birA
Conserved hypothetical protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
  
 0.440
nfo
Type IV apurinic/apyrimidinic endonuclease; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
      
 0.429
MCCL_1597
Conserved hypothetical protein; Similar to ABC transporter ATP-binding protein.
  
    0.427
MCCL_0467
Conserved hypothetical protein; Similar to anthranilate/para-aminobenzoate synthases component I.
  
  
 0.423
Your Current Organism:
Macrococcus caseolyticus
NCBI taxonomy Id: 458233
Other names: M. caseolyticus JCSC5402, Macrococcus caseolyticus JCSC5402, Macrococcus caseolyticus str. JCSC5402, Macrococcus caseolyticus strain JCSC5402
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