dinB protein (Macrococcus caseolyticus) - STRING interaction network

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dinB

DNA-damage-inducible protein P homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (354 aa)

Predicted Functional Partners:

dnaN

0.950

recA

0.713

lexA

0.654

polA

0.601

MCCL_1543

0.601

MCCL_0728

0.541

MCCL_1742

0.541

MCCL_0906

0.540

dnaE

0.514

recQ

0.501

Your Current Organism:

Macrococcus caseolyticus

NCBI taxonomy Id: 458233
Other names: M. caseolyticus JCSC5402, Macrococcus caseolyticus JCSC5402, Macrococcus caseolyticus str. JCSC5402, Macrococcus caseolyticus strain JCSC5402

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCCL_0728	dinB	MCCL_0728	MCCL_1628	FtsW/RodA/SpoVE family cell division protein homolog; Belongs to the SEDS family.	DNA-damage-inducible protein P homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.	0.541
MCCL_0728	dnaE	MCCL_0728	MCCL_1369	FtsW/RodA/SpoVE family cell division protein homolog; Belongs to the SEDS family.	DNA polymerase III alpha chain.	0.416
MCCL_0728	dnaN	MCCL_0728	MCCL_0002	FtsW/RodA/SpoVE family cell division protein homolog; Belongs to the SEDS family.	DNA polymerase III beta chain, sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is requir [...]	0.410
MCCL_0728	polA	MCCL_0728	MCCL_1357	FtsW/RodA/SpoVE family cell division protein homolog; Belongs to the SEDS family.	DNA polymerase I homolog; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.459
MCCL_0906	dinB	MCCL_0906	MCCL_1628	Cro/CI family transcriptional regulator homolog.	DNA-damage-inducible protein P homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.	0.540
MCCL_0906	recA	MCCL_0906	MCCL_0875	Cro/CI family transcriptional regulator homolog.	Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.845
MCCL_1543	dinB	MCCL_1543	MCCL_1628	Conserved hypothetical protein; Similar to phage-related protein.	DNA-damage-inducible protein P homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.	0.601
MCCL_1543	polA	MCCL_1543	MCCL_1357	Conserved hypothetical protein; Similar to phage-related protein.	DNA polymerase I homolog; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.474
MCCL_1543	recA	MCCL_1543	MCCL_0875	Conserved hypothetical protein; Similar to phage-related protein.	Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.883
MCCL_1742	dinB	MCCL_1742	MCCL_1628	Rod shape determining protein RodA; Belongs to the SEDS family.	DNA-damage-inducible protein P homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.	0.541
MCCL_1742	polA	MCCL_1742	MCCL_1357	Rod shape determining protein RodA; Belongs to the SEDS family.	DNA polymerase I homolog; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.461
dinB	MCCL_0728	MCCL_1628	MCCL_0728	DNA-damage-inducible protein P homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.	FtsW/RodA/SpoVE family cell division protein homolog; Belongs to the SEDS family.	0.541
dinB	MCCL_0906	MCCL_1628	MCCL_0906	DNA-damage-inducible protein P homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.	Cro/CI family transcriptional regulator homolog.	0.540
dinB	MCCL_1543	MCCL_1628	MCCL_1543	DNA-damage-inducible protein P homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.	Conserved hypothetical protein; Similar to phage-related protein.	0.601
dinB	MCCL_1742	MCCL_1628	MCCL_1742	DNA-damage-inducible protein P homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.	Rod shape determining protein RodA; Belongs to the SEDS family.	0.541
dinB	dnaE	MCCL_1628	MCCL_1369	DNA-damage-inducible protein P homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.	DNA polymerase III alpha chain.	0.514
dinB	dnaN	MCCL_1628	MCCL_0002	DNA-damage-inducible protein P homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.	DNA polymerase III beta chain, sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is requir [...]	0.950
dinB	lexA	MCCL_1628	MCCL_0995	DNA-damage-inducible protein P homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.	SOS regulatory LexA protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.654
dinB	polA	MCCL_1628	MCCL_1357	DNA-damage-inducible protein P homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.	DNA polymerase I homolog; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.601
dinB	recA	MCCL_1628	MCCL_0875	DNA-damage-inducible protein P homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.	Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.713

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