STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sigBSigma factor B; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (255 aa)    
Predicted Functional Partners:
rsbW
Anti-sigma regulatory factor; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
 
 
 0.997
rsbV
Anti-sigma B factor antagonist; Belongs to the anti-sigma-factor antagonist family.
 
 
 0.996
rsbU
Sigma B regulation protein RsbU.
 
 
 0.966
MCCL_1727
Conserved hypothetical protein; Similar to functionally unknown protein.
       0.797
rpoB
DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.780
rpoC
DNA-directed RNA polymerase beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.764
MCCL_1728
S1 RNA binding domain protein.
       0.721
MCCL_0977
Conserved hypothetical protein; Similar to ORF002 of bacteriophage 2638A.
  
  
 0.703
MCCL_0031
Conserved hypothetical protein; Similar to ThiJ/PfpI family protein.
   
  
 0.677
MCCL_1416
Conserved hypothetical protein; Similar to general stress protein.
 
    0.655
Your Current Organism:
Macrococcus caseolyticus
NCBI taxonomy Id: 458233
Other names: M. caseolyticus JCSC5402, Macrococcus caseolyticus JCSC5402, Macrococcus caseolyticus str. JCSC5402, Macrococcus caseolyticus strain JCSC5402
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.