gcaD protein (Macrococcus caseolyticus) - STRING interaction network

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gcaD

UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (452 aa)

Predicted Functional Partners:

glmM

0.976

prs

0.962

murA

0.938

murZ

0.930

mnaA

0.925

MCCL_0670

0.918

glmS

0.917

MCCL_0649

0.915

capL

0.914

MCCL_0656

0.811

Your Current Organism:

Macrococcus caseolyticus

NCBI taxonomy Id: 458233
Other names: M. caseolyticus JCSC5402, Macrococcus caseolyticus JCSC5402, Macrococcus caseolyticus str. JCSC5402, Macrococcus caseolyticus strain JCSC5402

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCCL_0649	MCCL_0656	MCCL_0649	MCCL_0656	UTP-glucose-1-phosphate uridyltransferase.	NAD dependent epimerase/dehydratase family protein homolog.	0.924
MCCL_0649	gcaD	MCCL_0649	MCCL_1913	UTP-glucose-1-phosphate uridyltransferase.	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.915
MCCL_0649	glmM	MCCL_0649	MCCL_0323	UTP-glucose-1-phosphate uridyltransferase.	Phosphoglucosamine-mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	0.496
MCCL_0649	glmS	MCCL_0649	MCCL_0324	UTP-glucose-1-phosphate uridyltransferase.	Glucosamine-fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.	0.561
MCCL_0649	mnaA	MCCL_0649	MCCL_1764	UTP-glucose-1-phosphate uridyltransferase.	UDP-GlcNAc 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family.	0.867
MCCL_0649	murA	MCCL_0649	MCCL_1755	UTP-glucose-1-phosphate uridyltransferase.	UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.	0.825
MCCL_0649	murZ	MCCL_0649	MCCL_1778	UTP-glucose-1-phosphate uridyltransferase.	UDP-N-acetylglucosamine 1-carboxyvinyltransferase homolog; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.	0.825
MCCL_0656	MCCL_0649	MCCL_0656	MCCL_0649	NAD dependent epimerase/dehydratase family protein homolog.	UTP-glucose-1-phosphate uridyltransferase.	0.924
MCCL_0656	gcaD	MCCL_0656	MCCL_1913	NAD dependent epimerase/dehydratase family protein homolog.	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.811
MCCL_0670	capL	MCCL_0670	MCCL_0675	Capsular polysaccharide biosynthesis protein CapD homolog.	Capsular polysaccharide biosynthesis protein CapL; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.	0.966
MCCL_0670	gcaD	MCCL_0670	MCCL_1913	Capsular polysaccharide biosynthesis protein CapD homolog.	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.918
MCCL_0670	mnaA	MCCL_0670	MCCL_1764	Capsular polysaccharide biosynthesis protein CapD homolog.	UDP-GlcNAc 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family.	0.946
capL	MCCL_0670	MCCL_0675	MCCL_0670	Capsular polysaccharide biosynthesis protein CapL; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.	Capsular polysaccharide biosynthesis protein CapD homolog.	0.966
capL	gcaD	MCCL_0675	MCCL_1913	Capsular polysaccharide biosynthesis protein CapL; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.914
capL	mnaA	MCCL_0675	MCCL_1764	Capsular polysaccharide biosynthesis protein CapL; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.	UDP-GlcNAc 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family.	0.969
gcaD	MCCL_0649	MCCL_1913	MCCL_0649	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	UTP-glucose-1-phosphate uridyltransferase.	0.915
gcaD	MCCL_0656	MCCL_1913	MCCL_0656	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	NAD dependent epimerase/dehydratase family protein homolog.	0.811
gcaD	MCCL_0670	MCCL_1913	MCCL_0670	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	Capsular polysaccharide biosynthesis protein CapD homolog.	0.918
gcaD	capL	MCCL_1913	MCCL_0675	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	Capsular polysaccharide biosynthesis protein CapL; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.	0.914
gcaD	glmM	MCCL_1913	MCCL_0323	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	Phosphoglucosamine-mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	0.976

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