Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ftcdFormimidoyltransferase-cyclodeaminase (Formiminotransferase-cyclodeaminase) (FTCD); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (558 aa)    
Predicted Functional Partners:
folD
FolD bifunctional protein [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.941
hutI
Imidazolonepropionase (imidazolone-5-propionate hydrolase); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
  0.930
gcvT
Aminomethyltransferase (Glycine cleavage system T protein); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GcvT family.
  
 
 0.920
glyA
Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.918
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
    
 0.905
folA
Dihydrofolate reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.903
purN
Phosphoribosylglycinamide formyltransferase 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
  0.900
aspC
Aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
  0.826
CLOAM1245
Aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
  
 
  0.826
rocA
Delta-1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase); Function of strongly homologous gene; enzyme.
   
 
 0.819
Your Current Organism:
Cloacimonas acidaminovorans
NCBI taxonomy Id: 459349
Other names: C. Cloacimonas acidaminovorans str. Evry, Candidatus Cloacamonas acidaminovorans str. Evry, Candidatus Cloacimonas acidaminovorans str. Evry
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