Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hgdCActivator of (R)-2-hydroxyglutaryl-CoA dehydratase; Function of homologous gene experimentally demonstrated in an other organism; regulator. (254 aa)    
Predicted Functional Partners:
CLOAM0527
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
 
 0.920
CLOAM0915
Putative ApbE-like lipoprotein precursor; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
       0.773
folE2
Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate.
       0.773
CLOAM0917
Putative zinc protease (metalloendopeptidase) (ymxG module); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the peptidase M16 family.
       0.773
CLOAM0919
Putative Histidinol-phosphatase; Homologs of previously reported genes of unknown function; Belongs to the PHP hydrolase family. HisK subfamily.
       0.773
CLOAM0914
Hypothetical protein; No homology to any previously reported sequences.
       0.741
miaA
tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family.
 
      0.631
kce
3-keto-5-aminohexanoate cleavage enzyme; Involved in the anaerobic fermentation of lysine. Catalyzes the reversible reaction between 3-keto-5-aminohexanoate (KAH) and acetyl-CoA to form 3-aminobutyryl-CoA and acetoacetate. The reaction involves the deprotonation of KAH, the nucleophilic addition onto acetyl-CoA and the intramolecular transfer of the CoA moiety. Belongs to the KCE family.
       0.525
CLOAM0913
Putative B12-dependent ribonucleoside-diphosphate/-triphosphate reductase (nrdJ-like); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
       0.525
fprA
Nitric oxide reductase (Type A flavoprotein) (FMN-protein) (Flavoprotein A); Function of homologous gene experimentally demonstrated in an other organism; putative enzyme.
 
     0.437
Your Current Organism:
Cloacimonas acidaminovorans
NCBI taxonomy Id: 459349
Other names: C. Cloacimonas acidaminovorans str. Evry, Candidatus Cloacamonas acidaminovorans str. Evry, Candidatus Cloacimonas acidaminovorans str. Evry
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