STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folADihydrofolate reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (141 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.934
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
 
 0.931
gcvT
Aminomethyltransferase (Glycine cleavage system T protein); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GcvT family.
  
 
 0.924
purN
Phosphoribosylglycinamide formyltransferase 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 
 0.924
folC
FolC bifunctional protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family.
     
 0.923
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
    
 0.923
ftcd
Formimidoyltransferase-cyclodeaminase (Formiminotransferase-cyclodeaminase) (FTCD); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.904
hutU
Urocanate hydratase (Urocanase) (Imidazolonepropionate hydrolase); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.648
CLOAM1095
Transporter, putative (modular protein); Belongs to the MlaE permease family.
       0.612
CLOAM1097
Hypothetical protein; No homology to any previously reported sequences.
       0.608
Your Current Organism:
Cloacimonas acidaminovorans
NCBI taxonomy Id: 459349
Other names: C. Cloacimonas acidaminovorans str. Evry, Candidatus Cloacamonas acidaminovorans str. Evry, Candidatus Cloacimonas acidaminovorans str. Evry
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