STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
xthAExonuclease III. (256 aa)    
Predicted Functional Partners:
nth
Putative endonuclease III (nth-like); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
 0.993
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.887
CLOAM1536
Putative DNA polymerase III, beta chain (dnaN-like); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is require [...]
   
 0.876
rluB
Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family.
  
    0.852
gmbH
D,D-heptose 1,7-bisphosphate phosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the gmhB family.
   
 
 0.834
CLOAM1178
Putative tRNA/rRNA methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
     0.574
CLOAM1176
Putative increased membrane permeability protein or organic solvent tolerance protein (imp-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier.
       0.568
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
 
 0.527
CLOAM1179
Xanthine dehydrogenase accessory factor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; 14622263, 15294283.
       0.520
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.502
Your Current Organism:
Cloacimonas acidaminovorans
NCBI taxonomy Id: 459349
Other names: C. Cloacimonas acidaminovorans str. Evry, Candidatus Cloacamonas acidaminovorans str. Evry, Candidatus Cloacimonas acidaminovorans str. Evry
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