node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDM70099.1 | SDN30625.1 | SAMN04488137_1515 | SAMN04488137_4020 | Glutamate synthase (NADPH/NADH) large chain. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.461 |
SDM70099.1 | SDN30650.1 | SAMN04488137_1515 | SAMN04488137_4021 | Glutamate synthase (NADPH/NADH) large chain. | Homocysteine S-methyltransferase. | 0.632 |
SDM70099.1 | SDN32457.1 | SAMN04488137_1515 | SAMN04488137_4103 | Glutamate synthase (NADPH/NADH) large chain. | Glutamate synthase (NADPH/NADH) large chain. | 0.999 |
SDM70099.1 | folD | SAMN04488137_1515 | SAMN04488137_0850 | Glutamate synthase (NADPH/NADH) large chain. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.484 |
SDM70099.1 | gcvH | SAMN04488137_1515 | SAMN04488137_2805 | Glutamate synthase (NADPH/NADH) large chain. | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | 0.902 |
SDM70099.1 | gcvPA | SAMN04488137_1515 | SAMN04488137_2027 | Glutamate synthase (NADPH/NADH) large chain. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.919 |
SDM70099.1 | gcvPB | SAMN04488137_1515 | SAMN04488137_2026 | Glutamate synthase (NADPH/NADH) large chain. | Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.911 |
SDM70099.1 | gcvT | SAMN04488137_1515 | SAMN04488137_2028 | Glutamate synthase (NADPH/NADH) large chain. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.919 |
SDM70099.1 | glyA | SAMN04488137_1515 | SAMN04488137_0029 | Glutamate synthase (NADPH/NADH) large chain. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.908 |
SDN30625.1 | SDM70099.1 | SAMN04488137_4020 | SAMN04488137_1515 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glutamate synthase (NADPH/NADH) large chain. | 0.461 |
SDN30625.1 | SDN30650.1 | SAMN04488137_4020 | SAMN04488137_4021 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homocysteine S-methyltransferase. | 0.999 |
SDN30625.1 | SDN31795.1 | SAMN04488137_4020 | SAMN04488137_4073 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.534 |
SDN30625.1 | SDN32457.1 | SAMN04488137_4020 | SAMN04488137_4103 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glutamate synthase (NADPH/NADH) large chain. | 0.461 |
SDN30625.1 | folD | SAMN04488137_4020 | SAMN04488137_0850 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.919 |
SDN30625.1 | gcvH | SAMN04488137_4020 | SAMN04488137_2805 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | 0.916 |
SDN30625.1 | gcvPA | SAMN04488137_4020 | SAMN04488137_2027 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.876 |
SDN30625.1 | gcvPB | SAMN04488137_4020 | SAMN04488137_2026 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.911 |
SDN30625.1 | gcvT | SAMN04488137_4020 | SAMN04488137_2028 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.929 |
SDN30625.1 | glyA | SAMN04488137_4020 | SAMN04488137_0029 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.903 |
SDN30650.1 | SDM70099.1 | SAMN04488137_4021 | SAMN04488137_1515 | Homocysteine S-methyltransferase. | Glutamate synthase (NADPH/NADH) large chain. | 0.632 |