node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
UF70_0802 | gcvT | UF70_0802 | UF70_1110 | Protein serine/threonine phosphatase PrpC. | Aminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. | 0.927 |
UF70_1113 | aroK | UF70_1113 | UF70_1111 | Late competence protein ComGF. | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.849 |
UF70_1113 | gcvPA | UF70_1113 | UF70_1109 | Late competence protein ComGF. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.739 |
UF70_1113 | gcvPB | UF70_1113 | UF70_1108 | Late competence protein ComGF. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.739 |
UF70_1113 | gcvT | UF70_1113 | UF70_1110 | Late competence protein ComGF. | Aminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. | 0.748 |
UF70_2017 | UF70_2258 | UF70_2017 | UF70_2258 | Biotinyl-lipoyl attachment domain protein. | 5,10-methylenetetrahydrofolate reductase. | 0.432 |
UF70_2017 | gcvPA | UF70_2017 | UF70_1109 | Biotinyl-lipoyl attachment domain protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.709 |
UF70_2017 | gcvPB | UF70_2017 | UF70_1108 | Biotinyl-lipoyl attachment domain protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.831 |
UF70_2017 | gcvT | UF70_2017 | UF70_1110 | Biotinyl-lipoyl attachment domain protein. | Aminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. | 0.909 |
UF70_2017 | glyA | UF70_2017 | UF70_1458 | Biotinyl-lipoyl attachment domain protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.527 |
UF70_2258 | UF70_2017 | UF70_2258 | UF70_2017 | 5,10-methylenetetrahydrofolate reductase. | Biotinyl-lipoyl attachment domain protein. | 0.432 |
UF70_2258 | folD | UF70_2258 | UF70_0656 | 5,10-methylenetetrahydrofolate reductase. | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.684 |
UF70_2258 | gcvH | UF70_2258 | UF70_0508 | 5,10-methylenetetrahydrofolate reductase. | Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. | 0.704 |
UF70_2258 | gcvPA | UF70_2258 | UF70_1109 | 5,10-methylenetetrahydrofolate reductase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.432 |
UF70_2258 | gcvPB | UF70_2258 | UF70_1108 | 5,10-methylenetetrahydrofolate reductase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.583 |
UF70_2258 | gcvT | UF70_2258 | UF70_1110 | 5,10-methylenetetrahydrofolate reductase. | Aminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. | 0.854 |
UF70_2258 | glyA | UF70_2258 | UF70_1458 | 5,10-methylenetetrahydrofolate reductase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.971 |
aroK | UF70_1113 | UF70_1111 | UF70_1113 | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | Late competence protein ComGF. | 0.849 |
aroK | gcvPA | UF70_1111 | UF70_1109 | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.766 |
aroK | gcvPB | UF70_1111 | UF70_1108 | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.766 |