STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ORB11333.116S/23S rRNA (cytidine-2'-O)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)    
Predicted Functional Partners:
nadK
NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
  
 0.979
ORB11335.1
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
 
  
 0.864
rsmG
16S rRNA (guanine(527)-N(7))-methyltransferase RsmG; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
  
   
 0.831
ORB15331.1
Nicotinamidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.792
gyrB
DNA topoisomerase (ATP-hydrolyzing) subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...]
     
 0.788
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
  
 0.788
whiB-2
WhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
      
 0.787
eis
GNAT family N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.787
rplC
50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
     
 0.787
BST37_14390
Hypothetical protein; Incomplete; partial in the middle of a contig; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.786
Your Current Organism:
Mycobacterium noviomagense
NCBI taxonomy Id: 459858
Other names: CIP 109766, DSM 45145, JCM 16367, M. noviomagense, Mycobacterium noviomagense van Ingen et al. 2009, strain NLA000500338
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