clpA protein (Legionella steigerwaltii) - STRING interaction network

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Score

clpA

ATP binding protease component ClpA; Belongs to the ClpA/ClpB family. (754 aa)

Predicted Functional Partners:

clpS

0.992

dnaK

0.967

clpP

0.924

grpE

0.859

Lstg_0420

0.832

sunS

0.829

htpG

0.807

dnaJ

0.802

lon

0.732

hslU

0.716

Your Current Organism:

Legionella steigerwaltii

NCBI taxonomy Id: 460
Other names: ATCC 35302, CCUG 29674, CCUG 56441, CIP 103851, DSM 23076, JCM 7558, L. steigerwaltii, NCTC 11991, strain SC-18-C9

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lstg_0420	clpA	Lstg_0420	Lstg_0422	O-antigen biosynthesis protein.	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	0.832
Lstg_0420	clpS	Lstg_0420	Lstg_0423	O-antigen biosynthesis protein.	Regulatory protein for ClpA substrate specificity; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.	0.793
Lstg_0420	sunS	Lstg_0420	Lstg_0421	O-antigen biosynthesis protein.	Lipopolysaccharide biosynthesis glycosyltransferase.	0.878
clpA	Lstg_0420	Lstg_0422	Lstg_0420	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	O-antigen biosynthesis protein.	0.832
clpA	clpP	Lstg_0422	Lstg_0895	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.924
clpA	clpS	Lstg_0422	Lstg_0423	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	Regulatory protein for ClpA substrate specificity; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.	0.992
clpA	dnaJ	Lstg_0422	Lstg_1745	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]	0.802
clpA	dnaK	Lstg_0422	Lstg_1744	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.967
clpA	grpE	Lstg_0422	Lstg_1743	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	Heat-shock protein GrpE(HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sever [...]	0.859
clpA	hslU	Lstg_0422	Lstg_1352	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	ATP-dependent protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	0.716
clpA	htpG	Lstg_0422	Lstg_1913	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	Class III heat-shock protein HtpG(molecular chaperone); Molecular chaperone. Has ATPase activity.	0.807
clpA	lon	Lstg_0422	Lstg_0893	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.	0.732
clpA	sunS	Lstg_0422	Lstg_0421	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	Lipopolysaccharide biosynthesis glycosyltransferase.	0.829
clpP	clpA	Lstg_0895	Lstg_0422	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	ATP binding protease component ClpA; Belongs to the ClpA/ClpB family.	0.924
clpP	clpS	Lstg_0895	Lstg_0423	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Regulatory protein for ClpA substrate specificity; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.	0.890
clpP	dnaJ	Lstg_0895	Lstg_1745	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]	0.483
clpP	dnaK	Lstg_0895	Lstg_1744	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.787
clpP	grpE	Lstg_0895	Lstg_1743	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Heat-shock protein GrpE(HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sever [...]	0.753
clpP	hslU	Lstg_0895	Lstg_1352	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	ATP-dependent protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	0.635
clpP	htpG	Lstg_0895	Lstg_1913	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Class III heat-shock protein HtpG(molecular chaperone); Molecular chaperone. Has ATPase activity.	0.700