| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Hgd | acsB | Lstg_0850 | Lstg_0849 | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.929 |
| Hgd | aldA | Lstg_0850 | Lstg_0235 | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.669 |
| Hgd | bioA | Lstg_0850 | Lstg_2017 | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.695 |
| Hgd | echA8 | Lstg_0850 | Lstg_0964 | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. | enoyl-CoA hydratase. | 0.994 |
| Hgd | fadB | Lstg_0850 | Lstg_0236 | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. | 3-hydroxyacyl CoA dehydrogenase oxidoreductase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.843 |
| Hgd | garR | Lstg_0850 | Lstg_2133 | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. | 3-hydroxyisobutyrate dehydrogenase. | 0.739 |
| Hgd | mccA | Lstg_0850 | Lstg_0091 | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. | Acyl CoA carboxylase subunit alpha. | 0.719 |
| Hgd | mmsA | Lstg_0850 | Lstg_0851 | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. | Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase. | 0.893 |
| Hgd | ppsC | Lstg_0850 | Lstg_0906 | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. | Quinone oxidoreductase. | 0.678 |
| Hgd | yfcX | Lstg_0850 | Lstg_0351 | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. | Enoyl CoA hydratase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.843 |
| acsB | Hgd | Lstg_0849 | Lstg_0850 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. | 0.929 |
| acsB | aldA | Lstg_0849 | Lstg_0235 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.744 |
| acsB | echA8 | Lstg_0849 | Lstg_0964 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | enoyl-CoA hydratase. | 0.524 |
| acsB | fadB | Lstg_0849 | Lstg_0236 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 3-hydroxyacyl CoA dehydrogenase oxidoreductase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.953 |
| acsB | garR | Lstg_0849 | Lstg_2133 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 3-hydroxyisobutyrate dehydrogenase. | 0.510 |
| acsB | mccA | Lstg_0849 | Lstg_0091 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Acyl CoA carboxylase subunit alpha. | 0.607 |
| acsB | mmsA | Lstg_0849 | Lstg_0851 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase. | 0.880 |
| acsB | ppsC | Lstg_0849 | Lstg_0906 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Quinone oxidoreductase. | 0.521 |
| acsB | yfcX | Lstg_0849 | Lstg_0351 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Enoyl CoA hydratase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.947 |
| aldA | Hgd | Lstg_0235 | Lstg_0850 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. | 0.669 |