| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Lstg_0876 | fabG_4-2 | Lstg_0876 | Lstg_1015 | Trp repressor. | 3-hydroxyacyl-CoA dehydrogenase. | 0.507 |
| Lstg_0876 | hisA | Lstg_0876 | Lstg_0882 | Trp repressor. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.756 |
| Lstg_0876 | hisB | Lstg_0876 | Lstg_0880 | Trp repressor. | Histidinol-phosphatase/imisazoleglycerol- phosphat e dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.907 |
| Lstg_0876 | hisC | Lstg_0876 | Lstg_0879 | Trp repressor. | Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase). | 0.830 |
| Lstg_0876 | hisD | Lstg_0876 | Lstg_0878 | Trp repressor. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.848 |
| Lstg_0876 | hisF | Lstg_0876 | Lstg_0883 | Trp repressor. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.736 |
| Lstg_0876 | hisG | Lstg_0876 | Lstg_0877 | Trp repressor. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.853 |
| Lstg_0876 | hisH | Lstg_0876 | Lstg_0881 | Trp repressor. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.859 |
| Lstg_0876 | hisIE | Lstg_0876 | Lstg_0884 | Trp repressor. | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | 0.751 |
| Lstg_0876 | pyrE | Lstg_0876 | Lstg_0875 | Trp repressor. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.539 |
| fabG_4-2 | Lstg_0876 | Lstg_1015 | Lstg_0876 | 3-hydroxyacyl-CoA dehydrogenase. | Trp repressor. | 0.507 |
| fabG_4-2 | hisA | Lstg_1015 | Lstg_0882 | 3-hydroxyacyl-CoA dehydrogenase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.507 |
| fabG_4-2 | hisC | Lstg_1015 | Lstg_0879 | 3-hydroxyacyl-CoA dehydrogenase. | Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase). | 0.526 |
| fabG_4-2 | hisD | Lstg_1015 | Lstg_0878 | 3-hydroxyacyl-CoA dehydrogenase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.795 |
| fabG_4-2 | hisF | Lstg_1015 | Lstg_0883 | 3-hydroxyacyl-CoA dehydrogenase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.507 |
| fabG_4-2 | hisG | Lstg_1015 | Lstg_0877 | 3-hydroxyacyl-CoA dehydrogenase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.507 |
| fabG_4-2 | hisH | Lstg_1015 | Lstg_0881 | 3-hydroxyacyl-CoA dehydrogenase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.507 |
| fabG_4-2 | hisIE | Lstg_1015 | Lstg_0884 | 3-hydroxyacyl-CoA dehydrogenase. | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | 0.507 |
| hisA | Lstg_0876 | Lstg_0882 | Lstg_0876 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Trp repressor. | 0.756 |
| hisA | fabG_4-2 | Lstg_0882 | Lstg_1015 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 3-hydroxyacyl-CoA dehydrogenase. | 0.507 |
