Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ywdHAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (456 aa)    
Predicted Functional Partners:
Lstg_1863
acyl-CoA synthetase.
  
 0.915
frmA
Alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
  
 0.897
mmsA
Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase.
  
  
 
0.896
Hgd
3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.
  
 
 0.887
nylA
Amidase; Belongs to the amidase family.
  
  
  0.886
acsB
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
   
 0.882
Lstg_0616
Alcohol dehydrogenase.
   
  0.880
yahK
Putative hydroxyacid dehydrogenase.
   
  0.880
ackA
Acetate kinase (Acetokinase); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
    
 0.873
yccX
Acylphosphatase.
     
  0.869
Your Current Organism:
Legionella steigerwaltii
NCBI taxonomy Id: 460
Other names: ATCC 35302, CCUG 29674, CCUG 56441, CIP 103851, DSM 23076, JCM 7558, L. steigerwaltii, NCTC 11991, strain SC-18-C9
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